{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:46:34Z","timestamp":1777671994889,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The Delta variant of COVID-19 has been associated with severe disease causing a surge in the second half of 2021. Atypical pathogens can be present in those in particular with severe ARDS and can contribute to excess morbidity and mortality. We must maintain a high level of suspicion for these pathogens as this can present an opportunity to dramatically improve the prognosis of a patient with COVID-19 ARDS. However, lend caution to Mycoplasma IgM serology as this can be a false-positive. If suspicion remains high for Mycoplasma pneumoniae infection, sputum polymerase chain reaction (PCR) for M pneumoniae is the gold standard for diagnosis. We present the case of a 42-year-old female with COVID-19 Delta variant presumed ARDS who had co-infection with M pneumoniae confirmed by endotracheal sputum aspirate PCR with rapidly improving oxygenation and extubation within 4 days of effective antibiotic therapy.<\/jats:p>","DOI":"10.1177\/23247096221129925","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T09:38:15Z","timestamp":1665481095000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Mycoplasma pneumoniae<\/i>\n                    COVID-19 Delta Variant Co-Infection Mimicking COVID-19 ARDS"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-2289","authenticated-orcid":false,"given":"James","family":"Crosby","sequence":"first","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME Programs, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Semon","sequence":"additional","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME Programs, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-0964","authenticated-orcid":false,"given":"Subramanya Shyam","family":"Ganti","sequence":"additional","affiliation":[{"name":"Appalachian Regional Healthcare, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enid","family":"Klauber-Choephel","sequence":"additional","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME Programs, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Abraham","sequence":"additional","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME Programs, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"bibr1-23247096221129925","unstructured":"Bhimraj A, Morgan RL, Shumaker AH, et al. Infectious diseases society of America guidelines on the treatment and management of patients with COVID-19(Version 5.0.1). Infectious Diseases Society of America 2021. Date unknown. https:\/\/www.idsociety.org\/globalassets\/idsa\/practice-guidelines\/covid-19\/treatment\/idsa-covid-19-gl-tx-and-mgmt-v5.1.0.pdf. 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