{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:49:08Z","timestamp":1780890548443,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Primary ovarian non-Hodgkin lymphoma is a rare lymphoma that is often associated with diagnostic delays, initial misdiagnosis, and inappropriate management. We report a case of ovarian diffuse large B-cell lymphoma (DLBCL) in a young female who initially presented with generalized fatigue, lower abdominal discomfort, and 40 pounds of unintentional weight loss. She subsequently had a computed tomography of abdomen done that showed fatty liver, hepatomegaly, and a left heterogeneous ovarian mass measuring about 4 \u00d7 4.2 cm. Transvaginal ultrasound was also done that showed a heterogeneous solid left adnexal mass measuring 7.4 \u00d7 5.6 \u00d7 6.6 cm. She subsequently had a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Immunohistochemistry (IHC) showed the malignant cells expressing PAX5, CD20, and BCL2 with a Ki-67 proliferation index greater than 90%. The cells were negative for AE1\/AE3, S100, CD30, and cyclin D1. Aggressive B-cell lymphoma fluorescence in situ hybridisation (FISH) panel was positive for rearrangement of BCL6 and MYC, with no evidence of BCL2 rearrangement, consistent with a double-hit high-grade B-cell lymphoma. Immunohistochemistry for BCL6 and MU M1 showed positive staining in the malignant cells. CD10 was negative. The staining profile was consistent with nongerminal center B-cell-like type of DLBCL. Ovarian lymphoma is a very rare entity; the presence of an enlarged ovarian tumor should raise the suspicion of ovarian lymphoma, and our case also emphasizes on the use of IHC markers in diagnosing the ovarian DLBCL.<\/jats:p>","DOI":"10.1177\/23247096231154641","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T04:23:22Z","timestamp":1677299002000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A Rare Case of Ovarian Double-Hit\/Diffuse Large B-Cell Lymphoma: A Case Report and Review of Literature"],"prefix":"10.1177","volume":"11","author":[{"given":"Madhulika","family":"Urella","sequence":"first","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemnasom","family":"Nwanwene","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsh","family":"Sidda","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Pacioles","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"bibr1-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30404"},{"key":"bibr2-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1179\/102453308X316149"},{"key":"bibr3-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.02.010"},{"key":"bibr4-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-012-0200-6"},{"key":"bibr5-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199302000-00007"},{"key":"bibr6-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.4583"},{"key":"bibr7-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"bibr8-23247096231154641","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8907"},{"key":"bibr9-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/35049074"},{"issue":"3","key":"bibr10-23247096231154641","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4103\/0973-1482.136026","volume":"10","author":"Mondal SK","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"bibr11-23247096231154641","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.56333"},{"key":"bibr12-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq627"},{"key":"bibr13-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12982"},{"key":"bibr14-23247096231154641","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13463"},{"issue":"12","key":"bibr15-23247096231154641","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3026(18)30177-7","volume":"5","author":"Dunleavy K","year":"2018","journal-title":"Lancet Haematol"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231154641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096231154641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231154641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:14Z","timestamp":1777449794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096231154641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":15,"alternative-id":["10.1177\/23247096231154641"],"URL":"https:\/\/doi.org\/10.1177\/23247096231154641","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"23247096231154641"}}