{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:47:14Z","timestamp":1777672034254,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Hepatocellular carcinoma (HCC) is a primary liver malignancy known to occur majorly in patients with liver cirrhosis or those with a harbinger of risk factors like viral hepatitis, autoimmune liver disease, alpha-1 antitrypsin deficiency, alcoholic liver disease, and nonalcoholic fatty liver disease. The incidence of HCC has risen in the past 2 decades and currently ranks as the sixth most common cause of cancer-related death worldwide. Most cases are seen in adulthood, and only a very small percentage have been reported in adolescents with risk factors. The 2 pathologic subtypes of pediatric HCC are classic and fibrolamellar. Here, we discussed a very interesting rare case of a healthy male teenager with no apparent liver disease or risk factor who presented with right-upper-quadrant pain, normal alpha-fetoprotein level, and abdominal ultrasound showing a large hepatic mass. A liver biopsy was positive for HCC with fluorescent in situ hybridization showing a PRKACA complex gene pattern, favoring the fibrolamellar type.<\/jats:p>","DOI":"10.1177\/23247096231165744","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T04:36:50Z","timestamp":1682743010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["An Unusual Case of Hepatocellular Carcinoma in a Healthy Teenager"],"prefix":"10.1177","volume":"11","author":[{"given":"Onyinye","family":"Ugonabo","sequence":"first","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yochita","family":"Pulipati","sequence":"additional","affiliation":[{"name":"Kakatiya Medical College, Warangal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Elghezewi","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Miller","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Logan","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pantangi","family":"Pramod","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,29]]},"reference":[{"key":"bibr1-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-020-00494-w"},{"key":"bibr2-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3420-3"},{"key":"bibr3-23247096231165744","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v14.i6.1103"},{"key":"bibr4-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1956.02060020170015"},{"key":"bibr5-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.015"},{"key":"bibr6-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249484"},{"key":"bibr7-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2018.02.006"},{"key":"bibr8-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0398-2"},{"key":"bibr9-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30246"},{"key":"bibr10-23247096231165744","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2021.131"},{"key":"bibr11-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.030"},{"key":"bibr12-23247096231165744","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320604"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231165744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096231165744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231165744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:22Z","timestamp":1777449802000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096231165744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":12,"alternative-id":["10.1177\/23247096231165744"],"URL":"https:\/\/doi.org\/10.1177\/23247096231165744","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"23247096231165744"}}