{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:16:26Z","timestamp":1783113386817,"version":"3.54.6"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of various genetic mutations leading to complement abnormalities with overactivation of alternate complement pathway in response to a triggering infection. She also had splenic rupture without splenomegaly and was managed successfully without splenectomy.<\/jats:p>","DOI":"10.1177\/23247096231172467","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T05:32:22Z","timestamp":1685079142000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection"],"prefix":"10.1177","volume":"11","author":[{"given":"Sadia","family":"Shabir","sequence":"first","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb T","family":"Spencer","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arooj","family":"Tabassum","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Chandra","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasef","family":"Sayeh","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Safi","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Ud din","sequence":"additional","affiliation":[{"name":"The University of Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"bibr1-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"bibr2-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-60"},{"key":"bibr3-23247096231172467","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.260"},{"key":"bibr4-23247096231172467","first-page":"22073","volume":"27","author":"Thomas KE","year":"2022","journal-title":"Perm J"},{"key":"bibr5-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"bibr6-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1128\/iai.40.3.1011-1014.1983"},{"key":"bibr7-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1128\/iai.38.1.122-126.1982"},{"key":"bibr8-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001180"},{"key":"bibr9-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199806270-00018"},{"key":"bibr10-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00388.x"},{"key":"bibr11-23247096231172467","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000061"},{"key":"bibr12-23247096231172467","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.10.009"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231172467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096231172467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231172467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:27Z","timestamp":1777449807000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096231172467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":12,"alternative-id":["10.1177\/23247096231172467"],"URL":"https:\/\/doi.org\/10.1177\/23247096231172467","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"23247096231172467"}}