{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:47:28Z","timestamp":1777672048682,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Autoimmune hepatitis (AIH) is an extremely rare cause of chronic liver disease (CLD) in sub-Saharan Africa\u2014there have only been 3 reported cases of AIH in Nigeria, a country of about 200 million people. We report the first case of AIH in a male patient in Nigeria and highlight its unusual presentation. A 41-year-old man with jaundice and malaise for 3 months was referred for evaluation after investigations revealed deranged liver enzymes and a cirrhotic liver. Laboratory evaluation revealed high serum immunoglobulin G, but there was also marked elevation of serum ferritin and transferrin saturation, resulting in a diagnostic dilemma between AIH and an iron overload condition such as hemochromatosis. A liver biopsy was crucial in providing a definitive diagnosis of AIH. Despite its rarity, clinicians should maintain a high index of suspicion for AIH in sub-Saharan Africa and should proceed to a liver biopsy when the cause of CLD is unclear.<\/jats:p>","DOI":"10.1177\/23247096231175442","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:00:52Z","timestamp":1684468852000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune Hepatitis Disguised as Iron Overload Syndrome: Diagnostic Dilemma in a Nigerian Man"],"prefix":"10.1177","volume":"11","author":[{"given":"Onyinye","family":"Ugonabo","sequence":"first","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenechukwu","family":"Chudy-Onwugaje","sequence":"additional","affiliation":[{"name":"Memorial Hospital Belleville, IL, USA"},{"name":"Eurocare Multispecialty Hospital, Lagos, Nigeria"},{"name":"University of Pennsylvania, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"bibr1-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30344-9"},{"key":"bibr2-23247096231175442","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.3226"},{"key":"bibr3-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050408"},{"issue":"2","key":"bibr4-23247096231175442","first-page":"208","volume":"10","author":"Otegbayo JA","year":"2010","journal-title":"Afr Health Sci"},{"issue":"2","key":"bibr5-23247096231175442","first-page":"133","volume":"15","author":"Jemilohun AC","year":"2017","journal-title":"Ann Ib Postgrad Med"},{"key":"bibr6-23247096231175442","doi-asserted-by":"publisher","DOI":"10.4103\/jomt.jomt_37_20"},{"key":"bibr7-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21059"},{"key":"bibr8-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb19000.x"},{"key":"bibr9-23247096231175442","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413578"},{"key":"bibr10-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1159\/000440705"},{"key":"bibr11-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2017"},{"key":"bibr12-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/872987"},{"key":"bibr13-23247096231175442","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31065"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231175442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096231175442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231175442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:27Z","timestamp":1777449807000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096231175442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":13,"alternative-id":["10.1177\/23247096231175442"],"URL":"https:\/\/doi.org\/10.1177\/23247096231175442","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"23247096231175442"}}