{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:47:34Z","timestamp":1777672054647,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm that originates from mature post-thymic T-cells. Cutaneous manifestations are a common presentation in T-PLL but rarely are a presentation in the recurrent setting. Here, we describe the case of a 75-year-old female with a history of T-PLL\u2014who at the time of initial diagnosis did not exhibit any rash\u2014presenting with diffuse rash, facial swelling, sore throat, and dysphagia 7 months later and was found to have recurrent T-PLL. She had diffuse lymphadenopathy and diffuse skin lesions. Biopsy of the skin lesions also confirmed infiltration with T-PLL cells. After review of the literature, no previously reported cases of recurrent T-PLL presented as diffuse skin lesions. This case demonstrates that recurrent T-PLL may present with diffuse rash, respiratory distress, and anasarca. It is important to stay vigilant in patients with history of T-PLL to recognize signs of recurrent disease to allow prompt diagnosis and treatment.<\/jats:p>","DOI":"10.1177\/23247096231176223","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T08:44:51Z","timestamp":1684831491000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrence of T-Cell Prolymphocytic Leukemia With a Rare Presentation as Diffuse Generalized Skin Lesion"],"prefix":"10.1177","volume":"11","author":[{"given":"Mustafa","family":"Wasifuddin","sequence":"first","affiliation":[{"name":"Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Sabzposh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishi","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Pathology, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-6645","authenticated-orcid":false,"given":"Jen C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, 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