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We report a case of concomitant diagnosis of AIP and SLE in a 21-year-old woman who presented with recurrent acute abdominal, chest, and back pain associated with nausea and vomiting, followed by arthralgia, multiple joint pain, and rash. Investigations revealed severe hyponatremia related to SIADH (syndrome of inappropriate antidiuretic hormone secretion) with a positive SLE antibody panel and a positive urine screen for porphobilinogen. Molecular test confirmed the diagnosis of AIP with a pathogenic mutation in the HMBS gene.<\/jats:p>","DOI":"10.1177\/23247096231181856","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T08:15:31Z","timestamp":1687335331000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Rare Coexistence of Acute Intermittent Porphyria With Systemic Lupus Erythematous: Case Report and Literature Review"],"prefix":"10.1177","volume":"11","author":[{"given":"Asmaa","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tawam Hospital, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alhaj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tawam Hospital, Al Ain, 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