{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:47:45Z","timestamp":1777672065941,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Hepatic dysfunction is prevalent in patients receiving total parenteral nutrition (TPN), resulting from steatosis, cholestasis, and cholecystitis. Regular assessments and monitoring of TPN patients are essential, even for clinically stable patients on long-term TPN. Furthermore, it is crucial to establish a differential diagnosis for hepatic dysfunction and investigate for other possible causes of elevated liver enzymes and underlying liver conditions. We present the case of a 56-year-old female patient with severe protein-calorie malnutrition on TPN, who exhibited significantly elevated liver enzymes during the routine periodic assessment. Subsequent investigation revealed that the patient had been taking traditional Chinese herbal medications concurrently with TPN. After discontinuing the herbal medications, the patient\u2019s liver enzymes returned to normal levels within 3 weeks.<\/jats:p>","DOI":"10.1177\/23247096231181969","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:37:39Z","timestamp":1687757859000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Abnormal Liver Function Tests in a Patient Receiving Total Parenteral Nutrition"],"prefix":"10.1177","volume":"11","author":[{"given":"Tram","family":"Tran","sequence":"first","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-6766","authenticated-orcid":false,"given":"Daniel Sungku","family":"Rim","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Nolen-Doerr","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryellen","family":"Lopez","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngdoh","family":"Nah","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-9763","authenticated-orcid":false,"given":"Jeong-Hun","family":"Shin","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"},{"name":"Hanyang University and Hanyang University Guri Hospital, Guri, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"bibr1-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115621863."},{"key":"bibr2-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.03.005."},{"key":"bibr3-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617734528"},{"key":"bibr4-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617735089"},{"key":"bibr5-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1002\/cld.888"},{"key":"bibr6-23247096231181969","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.endonu.2015.03.008","volume":"62","author":"Murillo AZ","year":"2015","journal-title":"Endocrinol Nutr (Engl Ed)"},{"key":"bibr7-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2017.06.008"},{"key":"bibr8-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113445."},{"key":"bibr9-23247096231181969","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12109"},{"key":"bibr10-23247096231181969","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050588"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231181969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096231181969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096231181969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:32Z","timestamp":1777449812000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096231181969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"alternative-id":["10.1177\/23247096231181969"],"URL":"https:\/\/doi.org\/10.1177\/23247096231181969","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"23247096231181969"}}