{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:49:12Z","timestamp":1777672152067,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase. Anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase autoantibodies have been found in about two-thirds of patients with IMNM. This myopathy is usually idiopathic and there is a scarce literature concerning its association with connective tissue diseases. Herein, we report an unusual case of a young woman who presented with both rheumatoid arthritis and severe anti-SRP IMNM. Thankfully to a therapeutic protocol combining rituximab and cyclophosphamide, an important improvement was achieved, and notably no serious side effect was observed.<\/jats:p>","DOI":"10.1177\/23247096241231646","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:48:05Z","timestamp":1707893285000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy: A Case Report"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-2101","authenticated-orcid":false,"given":"Mohamed Reda","family":"Belkhribchia","sequence":"first","affiliation":[{"name":"Hassan II Regional Hospital, Dakhla, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Alexander","family":"Lobrinus","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamyaa","family":"Semlil","sequence":"additional","affiliation":[{"name":"Hassan II Regional Hospital, Dakhla, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Chauveau","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz","family":"Ajrinija","sequence":"additional","affiliation":[{"name":"Hassan II Regional Hospital, Dakhla, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof","family":"Egervari","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zine Elabidine","family":"Ennhaili","sequence":"additional","affiliation":[{"name":"Hassan II Regional Hospital, Dakhla, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"bibr1-23247096241231646","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-018-0732-6"},{"key":"bibr2-23247096241231646","doi-asserted-by":"publisher","DOI":"10.1177\/23247096221150636"},{"key":"bibr3-23247096241231646","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00515-9"},{"key":"bibr4-23247096241231646","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.04.002"},{"key":"bibr5-23247096241231646","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06354-5"},{"issue":"3","key":"bibr6-23247096241231646","first-page":"781","volume":"55","author":"Ancu\u0163a C","year":"2014","journal-title":"Rom J Morphol Embryol"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241231646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096241231646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241231646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:54Z","timestamp":1777449834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096241231646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":6,"alternative-id":["10.1177\/23247096241231646"],"URL":"https:\/\/doi.org\/10.1177\/23247096241231646","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23247096241231646"}}