{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:02:52Z","timestamp":1780963372073,"version":"3.54.1"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Macrophage activation syndrome (MAS) is a form of secondary hemophagocytic lymphohistiocytosis (HLH) when it occurs in the context of rheumatologic disorders. HLH is a rare and potentially life-threatening syndrome characterized by excessive immune system activation. It is mainly seen in children and can be genetic based or related to infections, malignancies, rheumatologic disorders, or immunodeficiency syndromes. MAS can present with nonspecific symptoms, leading to a delay in diagnosis. This report describes a case of a 64-year-old female with marginal zone lymphoma and systemic lupus erythematosus who presented with a purpuric rash and acute kidney injury. She underwent a kidney biopsy and was diagnosed with MAS. This case highlights the importance of promptly recognizing MAS\u2019s symptoms and signs, allowing timely diagnosis and early therapeutic intervention. This potentially fatal condition tends to respond well to rapid treatment initiation with corticosteroids and to address the underlying condition.<\/jats:p>","DOI":"10.1177\/23247096241244732","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T07:58:41Z","timestamp":1712303921000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Marginal Zone Lymphoma Manifesting as Macrophage Activation Syndrome: A Case Report"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-7820","authenticated-orcid":false,"given":"Niloufar","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahibzadi Mahrukh","family":"Noor","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Kordasti","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"Guy\u2019s Hospital, London, UK"},{"name":"Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Akhtari","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayna","family":"Norouzi","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrbod","family":"Vakhshoori","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Abdipour","sequence":"additional","affiliation":[{"name":"Loma Linda University Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"bibr1-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618."},{"key":"bibr2-23247096241244732","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35670."},{"key":"bibr3-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key006."},{"key":"bibr4-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.06.010."},{"key":"bibr5-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-020-01342-4."},{"key":"bibr6-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw076."},{"key":"bibr7-23247096241244732","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13365."},{"key":"bibr8-23247096241244732","doi-asserted-by":"publisher","DOI":"10.1177\/2324709618812196."}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241244732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096241244732","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241244732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:03:58Z","timestamp":1777449838000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096241244732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":8,"alternative-id":["10.1177\/23247096241244732"],"URL":"https:\/\/doi.org\/10.1177\/23247096241244732","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23247096241244732"}}