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We report a case of a 12-year-old female who complained of fever, night sweating, significant weight loss, and tender right cervical lymph node enlargement for 2 months. A full workup including laboratory tests and imaging studies, an excisional biopsy, and histopathological analysis were done, and the diagnosis of KFD was confirmed. The patient was treated with analgesia and oral prednisolone, resulting in good improvement. A high degree of clinical suspicion is imperative for physicians, given the rarity of the disease and the associated diagnostic challenges.<\/jats:p>","DOI":"10.1177\/23247096241246618","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T01:53:20Z","timestamp":1712886800000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Kikuchi-Fujimoto Disease: A Case Report of Prolonged Fever and Lymphadenopathy in a Young Girl"],"prefix":"10.1177","volume":"12","author":[{"given":"Ezat Mohammed","family":"Anini","sequence":"first","affiliation":[{"name":"Palestine Polytechnic University, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha Mahmoud","family":"AlBaik","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Tayseer","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7602-597X","authenticated-orcid":false,"given":"Nasim Afif","family":"AbuKaresh","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-7000","authenticated-orcid":false,"given":"Maram","family":"Albandak","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafat","family":"Alshalaldeh","sequence":"additional","affiliation":[{"name":"Hebron Governmental Hospital, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motaz","family":"Natsheh","sequence":"additional","affiliation":[{"name":"Al Ahli Hospital, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawzy M.","family":"Abunejma","sequence":"additional","affiliation":[{"name":"Palestinian Red Crescent Society Hospital, Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"bibr1-23247096241246618","doi-asserted-by":"publisher","DOI":"10.5858\/134.2.289"},{"key":"bibr2-23247096241246618","unstructured":"Masab M, Surmachevska N, Farooq H. 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