{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:10:58Z","timestamp":1789513858460,"version":"build-2803163510"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Subcutaneous panniculitis-like T-cell lymphoma (SPTLP), a unique variant of primary cutaneous T-cell lymphomas, clinically mimics subcutaneous panniculitis. It is typified by the development of multiple plaques or subcutaneous erythematous nodules, predominantly on the extremities and trunk. Epidemiological findings reveal a greater incidence in females than males, affecting a wide demographic, including pediatric and adult cohorts, with a median onset age of around 30 years. Diagnosis of SPTLP is complex, hinging on skin biopsy analyses and the identification of T-cell lineage-specific immunohistochemical markers. Treatment modalities for SPTLP are varied; while corticosteroids may be beneficial initially for many patients, a substantial number require chemotherapy, especially in cases of poor response or relapse. Generally, SPTLP progresses slowly, yet approximately 20% of cases advance to hemophagocytic lymphohistiocytosis (HLH), often correlating with a negative prognosis. We report a case of a young male patient presenting with prolonged fever, multiple skin lesions accompanied by HLH, a poor clinical course, and eventual death, diagnosed postmortem with SPTLP. In addition, we also present a literature review of the current evidence of some updates related to SPTLP.<\/jats:p>","DOI":"10.1177\/23247096241253337","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:00:33Z","timestamp":1715666433000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Subcutaneous Panniculitis-Like T-Cell Lymphoma With Hemophagocytic Lymphohistiocytosis"],"prefix":"10.1177","volume":"12","author":[{"given":"Nhu Tung","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Pathology, Tam Anh General Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-4997","authenticated-orcid":false,"given":"Khac Tuyen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Military Hospital 175, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Thi","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tam Anh General Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuyen Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong Thao","family":"Trinh","sequence":"additional","affiliation":[{"name":"FV Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-4387","authenticated-orcid":false,"given":"Van Trung","family":"Hoang","sequence":"additional","affiliation":[{"name":"Thien Hanh Hospital, Buon Ma Thuot, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"bibr1-23247096241253337","doi-asserted-by":"publisher","DOI":"10.5858\/133.2.303"},{"key":"bibr2-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/824528"},{"key":"bibr3-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"bibr4-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2017.11929537"},{"key":"bibr5-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0854-9"},{"key":"bibr6-23247096241253337","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2018.11.01"},{"key":"bibr7-23247096241253337","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.882007"},{"key":"bibr8-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.1243"},{"key":"bibr9-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199807000-00010"},{"key":"bibr10-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005235.x"},{"key":"bibr11-23247096241253337","unstructured":"Musick SR, Lynch DT. Subcutaneous Panniculitis-Like T-Cell Lymphoma. StatPearls Publishing. Accessed 1 March 2024. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538517"},{"key":"bibr12-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.05.001"},{"key":"bibr13-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2914"},{"key":"bibr14-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009283"},{"key":"bibr15-23247096241253337","volume":"22","author":"Mody A","year":"2021","journal-title":"Am J Case Rep"},{"key":"bibr16-23247096241253337","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-140982"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241253337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096241253337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241253337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:00Z","timestamp":1777449840000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096241253337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":16,"alternative-id":["10.1177\/23247096241253337"],"URL":"https:\/\/doi.org\/10.1177\/23247096241253337","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23247096241253337"}}