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These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.<\/jats:p>","DOI":"10.1177\/23247096241253348","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T08:05:05Z","timestamp":1715933105000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2772-6085","authenticated-orcid":false,"given":"Lefika","family":"Bathobakae","sequence":"first","affiliation":[{"name":"St. Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rammy","family":"Bashir","sequence":"additional","affiliation":[{"name":"St. George\u2019s University, Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Vera","sequence":"additional","affiliation":[{"name":"St. George\u2019s University, Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Yasin","sequence":"additional","affiliation":[{"name":"St. George\u2019s University, Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atang","family":"Koodirile","sequence":"additional","affiliation":[{"name":"American University of Antigua, Coolidge, Antigua"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratul","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"St. Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehandar","family":"Kumar","sequence":"additional","affiliation":[{"name":"St. Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"bibr1-23247096241253348","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/595968"},{"issue":"4","key":"bibr2-23247096241253348","first-page":"197","volume":"8","author":"Gerrish ST","year":"2008","journal-title":"Ochsner J"},{"key":"bibr3-23247096241253348","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20230505"},{"key":"bibr4-23247096241253348","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20220962"},{"key":"bibr5-23247096241253348","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080694"},{"key":"bibr6-23247096241253348","doi-asserted-by":"publisher","DOI":"10.4103\/1117-6806.199960"},{"key":"bibr7-23247096241253348","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v5.i6.102"},{"key":"bibr8-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1814254"},{"key":"bibr9-23247096241253348","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/8444.4475"},{"key":"bibr10-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880099"},{"key":"bibr11-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.107666"},{"key":"bibr12-23247096241253348","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23108"},{"key":"bibr13-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3810-7"},{"key":"bibr14-23247096241253348","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4344"},{"key":"bibr15-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21419"},{"key":"bibr16-23247096241253348","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14880"},{"key":"bibr17-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy095"},{"key":"bibr18-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693040"},{"key":"bibr19-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-5-121"},{"key":"bibr20-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.11.020"},{"key":"bibr21-23247096241253348","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-229839"},{"key":"bibr22-23247096241253348","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6519-20"},{"key":"bibr23-23247096241253348","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20195433"},{"key":"bibr24-23247096241253348","unstructured":"National Comprehensive Cancer Network. 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