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Dexmedetomidine is a common medication used to sedate ventilated patients in the intensive care unit and for nonintubated patients prior to a surgical procedure. As a highly selective alpha-2 agonist, dexmedetomidine provides sedation while reducing the need for anxiolytics or opioids. However, previous case reports suggest dexmedetomidine can induce fever in a variety of conditions. The purpose of this case report is to describe a patient who acquired a fever of 42.6\u00b0C in the setting of COVID-19 after administration of dexmedetomidine.<\/jats:p>","DOI":"10.1177\/23247096241260959","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T07:26:31Z","timestamp":1718263591000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Record Setting Temperatures in the Setting of SARS-CoV-2 Suggests Dexmedetomidine Drug-Induced Fever: A Case Report"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-685X","authenticated-orcid":false,"given":"Megan","family":"Meier","sequence":"first","affiliation":[{"name":"Veterans Affairs Eastern Colorado Healthcare System, Aurora, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-4275","authenticated-orcid":false,"given":"Becky S","family":"Linn","sequence":"additional","affiliation":[{"name":"University of Wyoming, Laramie, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"bibr1-23247096241260959","unstructured":"Lexi-Comp Online TM. 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