{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:14:39Z","timestamp":1782486879762,"version":"3.54.5"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Immune checkpoint inhibitors have become essential antineoplastic agents in medical oncology over the past decade. However, they are associated with potentially fatal multisystem abnormalities, with increasing concern in gastrointestinal tract and its associated organs. We present a patient with advanced renal cell carcinoma, who presented with acute liver failure after the first dose of combined immunotherapy with nivolumab and ipilimumab. A thorough evaluation for viral, metabolic, and autoimmune causes was unremarkable. He was managed with steroids and made significant improvement. To our knowledge, this is the first documented case of acute liver failure following ipilimumab and nivolumab.<\/jats:p>","DOI":"10.1177\/23247096241261505","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:44:26Z","timestamp":1718783066000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Checkpoint Inhibitor Induced Acute Liver Failure"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6421-630X","authenticated-orcid":false,"given":"Chukwunonso","family":"Ezeani","sequence":"first","affiliation":[{"name":"Baton Rouge General Medical Center, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogochukwu","family":"Ugochukwu","sequence":"additional","affiliation":[{"name":"Our lady of the Lake Regional Medical Center, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adejoke","family":"Johnson","sequence":"additional","affiliation":[{"name":"Jacobi Medical Center\/North Central Bronx Hospital, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lavie","sequence":"additional","affiliation":[{"name":"Mary Bird Perkins Cancer Center, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Chauvin","sequence":"additional","affiliation":[{"name":"Gastroenterology Associates, LLC, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"bibr1-23247096241261505","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020101"},{"key":"bibr2-23247096241261505","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00730"},{"key":"bibr3-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2023.102203"},{"key":"bibr4-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5090200"},{"key":"bibr5-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-023-01789-8"},{"key":"bibr6-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009431"},{"key":"bibr7-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2022.12.008"},{"key":"bibr8-23247096241261505","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32689"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241261505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096241261505","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241261505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:03Z","timestamp":1777449843000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096241261505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":8,"alternative-id":["10.1177\/23247096241261505"],"URL":"https:\/\/doi.org\/10.1177\/23247096241261505","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23247096241261505"}}