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We highlight a case of a 24-year-old female who presented with weakness of proximal muscles, periorbital edema, heliotrope rash, erosions on oral mucosa, and painful scaly rash on the lower extremities. Transcriptional intermediary factor-1 gamma Abs were positive, confirming inflammatory myopathy. Treatment with steroid pulse therapy and immunoglobulin led to improvement. Evaluation for malignancy yielded unremarkable results. This case underscores the importance of recognizing and managing DM with TIF-1\u03b3 Ab positive, even in atypical demographics, and highlights the need for comprehensive malignancy evaluation.<\/jats:p>","DOI":"10.1177\/23247096241263065","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:03:56Z","timestamp":1718957036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Anti-TIF-1\u03b3 Antibody Positive Dermatomyositis in Adulthood"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3679-7192","authenticated-orcid":false,"given":"Upasana","family":"Agrawal","sequence":"first","affiliation":[{"name":"Louisiana State University Health Sciences Center, Shreveport, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manush","family":"Sondhi","sequence":"additional","affiliation":[{"name":"Louisiana 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