{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:50:05Z","timestamp":1777672205567,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>This report describes a case of facial hyperpigmentation in a patient with Crohn\u2019s disease receiving adalimumab, a tumor necrosis factor (TNF)-alpha inhibitor. The onset of hyperpigmentation coincided with adalimumab administration, and its discontinuation resulted in significant improvement. Histopathological findings suggest a postinflammatory process at the dermo-epidermal junction. However, the precise mechanism remains unclear.<\/jats:p>","DOI":"10.1177\/23247096241265896","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:21:46Z","timestamp":1721888506000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Facial Hyperpigmentation: A Rare Side Effect of Adalimumab"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-8883","authenticated-orcid":false,"given":"Malek","family":"Mrad","sequence":"first","affiliation":[{"name":"RABTA Hospital, Tunis, Tunisia"},{"name":"University of Tunis El Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Tabka","sequence":"additional","affiliation":[{"name":"RABTA Hospital, Tunis, Tunisia"},{"name":"University of Tunis El Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmahane","family":"Souissi","sequence":"additional","affiliation":[{"name":"RABTA Hospital, Tunis, Tunisia"},{"name":"University of Tunis El Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Chelly","sequence":"additional","affiliation":[{"name":"RABTA Hospital, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Mokni","sequence":"additional","affiliation":[{"name":"RABTA Hospital, Tunis, Tunisia"},{"name":"University of Tunis El Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"bibr1-23247096241265896","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0296-7"},{"issue":"12","key":"bibr2-23247096241265896","volume":"14","author":"Alsisi GG","year":"2022","journal-title":"Cureus"},{"key":"bibr3-23247096241265896","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0697"},{"key":"bibr4-23247096241265896","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2017.09.565"},{"key":"bibr5-23247096241265896","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15268"},{"key":"bibr6-23247096241265896","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14016"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241265896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096241265896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096241265896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:05Z","timestamp":1777449845000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096241265896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":6,"alternative-id":["10.1177\/23247096241265896"],"URL":"https:\/\/doi.org\/10.1177\/23247096241265896","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23247096241265896"}}