{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:55:00Z","timestamp":1792601700148,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Co-infection with\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    in an immunocompetent host is rare but can occur. In this case, we present a patient with central nervous system tuberculosis (TB) and biopsy-proven spinal co-infections with TB and Aspergillosis. We highlight the complexities of treating a TB-Aspergillosis co-infection given drug-drug interactions between standard therapy for both conditions. Using susceptibilities for the\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    and carefully monitoring drug levels of the antifungal agents, we were able to optimally treat the co-infection. This patient was ultimately discharged on isoniazid 1200\u2009mg (15\u2009mg\/kg) daily, levofloxacin 750\u2009mg daily, rifabutin 450\u2009mg daily, and posaconazole 300\u2009mg twice daily with a tentative plan to treat for at least 1\u2009year with close outpatient follow-up. This case can serve as a guide for other providers who need to treat cases of TB and Aspergillosis co-infection by learning from our experience and paying attention to potential pitfalls.\n                  <\/jats:p>","DOI":"10.1177\/23247096251329684","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T17:40:05Z","timestamp":1743010805000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Tuberculous Meningitis With Concomitant Spinal Co-infection With Tuberculosis and\n                    <i>Aspergillosis<\/i>"],"prefix":"10.1177","volume":"13","author":[{"given":"Candice A.","family":"Sternberg","sequence":"first","affiliation":[{"name":"University of Miami, Miller School of Medicine, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Martinez","sequence":"additional","affiliation":[{"name":"Jackson Health System, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoola","family":"Olayiwola","sequence":"additional","affiliation":[{"name":"University of Miami, Miller School of Medicine, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Morel","family":"Almonte","sequence":"additional","affiliation":[{"name":"Jackson Health System, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Vu","sequence":"additional","affiliation":[{"name":"Jackson Health System, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Jackson Health System, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Montreuil","sequence":"additional","affiliation":[{"name":"University of Miami, Miller School of Medicine, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-1278","authenticated-orcid":false,"given":"Folusakin","family":"Ayoade","sequence":"additional","affiliation":[{"name":"University of Miami, Miller School of Medicine, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90192-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5030079"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010201"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30979-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.85"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190018760621s"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ571"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.747952"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00042-07"},{"key":"e_1_3_3_12_2","first-page":"149","volume-title":"The Microbiology of Central Nervous System Infections","author":"Soleiman-Meigooni S","unstructured":"Soleiman-Meigooni S. Chapter 9\u2014central nervous system tuberculosis. In: K Kon, M Rai, eds. The Microbiology of Central Nervous System Infections. 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