{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:51:44Z","timestamp":1777672304210,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Sickle cell disease (SCD), prevalent in African Americans, is associated with numerous complications, including infections and pulmonary manifestations. Necrotizing cavitary pneumonia, a rare but severe complication, poses significant diagnostic challenges in patients with SCD. We report a 27-year-old male with SCD and history of pulmonary infarction from pulmonary embolism who presented with bilateral wrist pain, cough, and chest pain and was found to have necrotizing cavitary pneumonia. Initial imaging revealed significant right upper lobe cavitary consolidation. Despite negative sputum cultures, blood cultures identified\n                    <jats:italic toggle=\"yes\">Staphylococcus epidermidis<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Granulicatella<\/jats:italic>\n                    , atypical pathogens in pneumonia cases. Pain crisis treatment and treatment with antibiotics for pneumonia displayed significant improvement in symptoms. Our case highlights the necessity of considering unusual pathogens in SCD patients presenting with pneumonia, particularly those with prior pulmonary complications. Infections remain a leading cause of morbidity and mortality in SCD, underscoring the importance of rapid diagnosis and tailored management. Vigilant monitoring of cavitary lesions and prompt recognition of atypical pathogens can mitigate risks of severe pulmonary complications and improve patient outcomes. Additional research is required to delineate the epidemiology of rare infections in SCD and establish effective treatment protocols.\n                  <\/jats:p>","DOI":"10.1177\/23247096251334241","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T05:36:21Z","timestamp":1744436181000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Unexpected\u2014Role of Unique Pathogens in Necrotizing Cavitary Pneumonia of Sickle Cell Disease: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7436-635X","authenticated-orcid":false,"given":"Jayalekshmi","family":"Jayakumar","sequence":"first","affiliation":[{"name":"The Brooklyn Hospital Centre, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasa","family":"Ginjupalli","sequence":"additional","affiliation":[{"name":"The Brooklyn Hospital Centre, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiqe","family":"Khan","sequence":"additional","affiliation":[{"name":"The Brooklyn Hospital Centre, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meher","family":"Ayyazuddin","sequence":"additional","affiliation":[{"name":"CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-2326","authenticated-orcid":false,"given":"Giovannie","family":"Isaac Coss","sequence":"additional","affiliation":[{"name":"Rush University Medical Centre, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ashar Ali","sequence":"additional","affiliation":[{"name":"New York Medical College, Valhalla, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmat","family":"Ullah","sequence":"additional","affiliation":[{"name":"The Brooklyn Hospital Centre, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Sickle Cell Anemia","author":"Ehsan M","year":"2023","unstructured":"Ehsan M, Maruvada S. 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A case report of necrotizing pneumonia due to Burkholderia cepacia syndrome. Cureus. 2024;16(1):e52955.","journal-title":"Cureus"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/345851"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/167.1.85"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7180\/kmj.2019.34.1.57"},{"key":"e_1_3_3_21_2","first-page":"125","article-title":"A rare cause of cavitary pneumonia","volume":"19","author":"Harsha NS","year":"2016","unstructured":"Harsha NS, Sandeepa HS, Hemantha Kumar S, et al A rare cause of cavitary pneumonia. Respir Med Case Rep. 2016;19:125-127.","journal-title":"Respir Med Case Rep"},{"issue":"1","key":"e_1_3_3_22_2","first-page":"22","article-title":"Necrotizing pneumonia or pulmonary gangrene: necrotizing pneumonia due to Staphylococcus epidermidis","volume":"4","author":"Carpio-Orantes LD.","year":"2018","unstructured":"Carpio-Orantes LD. Necrotizing pneumonia or pulmonary gangrene: necrotizing pneumonia due to Staphylococcus epidermidis. Community Acquir Infect. 2018;4(1):22-29.","journal-title":"Community Acquir Infect"},{"issue":"1","key":"e_1_3_3_23_2","first-page":"61","article-title":"Staphylococcus epidermidis necrotizing pneumonia and pneumatocele in a term infant","volume":"4","author":"Johan AJ","year":"2009","unstructured":"Johan AJ, Cheah FC. Staphylococcus epidermidis necrotizing pneumonia and pneumatocele in a term infant. 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