{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:52:26Z","timestamp":1777672346804,"version":"3.51.4"},"reference-count":2,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>When there is concern that a rash may be a drug eruption reaction, there are many well-known culprits such as antibiotics and phenytoin. When an uncommon or previously unknown offending medication is being considered to have caused a drug eruption, diagnostic skin biopsy can help confirm the diagnosis. Our patient is a 54-year-old female with past medical history of prediabetes and obesity. She had ST segment-elevation myocardial infarction that was treated appropriately with timely percutaneous coronary intervention, which included angioplasty and drug-eluting stent placement. She was maintained on treatment regimen, and over the next 3\u2009months, she developed a worsening maculopapular rash across her torso and upper extremities. Her biopsy showed superficial and mid-dermal perivascular lymphohistiocytic inflammation with focal spongiosis and scattered eosinophils, a common pathologic finding seen in drug eruptions. Although the patient was not taking any well-known offending agents, her ticagrelor was discontinued and she was transitioned to clopidogrel. Shortly after the transition, the patient\u2019s drug rash resolved without recurrence. Drug eruptions are a common etiology for rashes leading to presentation in primary care clinics. Our patient illustrates an exceedingly rare case of ticagrelor-induced drug reaction, as a review of the literature shows only 2 previously published case reports.<\/jats:p>","DOI":"10.1177\/23247096251350547","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:17:49Z","timestamp":1750223869000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biopsy Confirmed Skin Drug Eruption in Setting of Ticagrelor Use"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3942-1927","authenticated-orcid":false,"given":"Dre E","family":"Steinwehr","sequence":"first","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"},{"name":"Sanford Health, Fargo, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jena M","family":"Gales","sequence":"additional","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5576-8248","authenticated-orcid":false,"given":"Anya R","family":"de Leeuw","sequence":"additional","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"},{"name":"University of Arizona, Phoenix, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek S","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"Cunningham","sequence":"additional","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"},{"name":"Sanford Health, Fargo, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-3768","authenticated-orcid":false,"given":"Aaron A H","family":"Smith","sequence":"additional","affiliation":[{"name":"University of North Dakota School of Medicine and Health Sciences, Fargo, USA"},{"name":"Sanford Health, Fargo, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34800"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13890"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096251350547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096251350547","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096251350547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:33Z","timestamp":1777449873000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096251350547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":2,"alternative-id":["10.1177\/23247096251350547"],"URL":"https:\/\/doi.org\/10.1177\/23247096251350547","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"23247096251350547"}}