{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:52:35Z","timestamp":1777672355763,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Giant pheochromocytomas are rare tumors, typically exceeding 7\u2009cm in size. Most are noncatecholamine secreting due to tumor necrosis and connective tissue content. Their presentation can range from classic hyperadrenergic symptoms to vague gastrointestinal complaints. Larger tumors are associated with higher risks of metastasis, mortality, and perioperative complications. Our case presents a 31-year-old female who presented with the chief complaint of vomiting, associated with intermittent palpitations and elevated blood pressure, with subsequent imaging revealing an 8.7\u2009cm right adrenal mass. Complete resection of the mass showed a 10\u2009\u00d7\u20097\u2009\u00d7\u20093.9\u2009cm mass that occupied the entire adrenal medulla, consistent with a giant pheochromocytoma. This case contributes to the evidence supporting a minimally invasive approach as well as individualized management of giant pheochromocytomas. Furthermore, it emphasizes the importance of a high clinical suspicion in the context of vague symptoms.<\/jats:p>","DOI":"10.1177\/23247096251358668","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T07:56:16Z","timestamp":1752825376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical Presentation of Giant Pheochromocytoma Managed With Minimally Invasive Surgery"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3791-2033","authenticated-orcid":false,"given":"Vania","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Manzano","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliaa","family":"Al Sabbagh","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Howard","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Baker","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preetika","family":"Mauyra","sequence":"additional","affiliation":[{"name":"Command Hospital, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae163.196"},{"key":"e_1_3_3_3_2","unstructured":"National Cancer Institute. Pheochromocytoma treatment and paraganglioma treatment (PDQ)- Health profressional version. National Cancer Institute. 2024. 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J Med Case Rep. 2023;17(1):373.","journal-title":"J Med Case Rep"},{"issue":"7","key":"e_1_3_3_12_2","article-title":"Giant pheochromocytoma: a case report and review of the literature","volume":"9","author":"Zhang J","year":"2015","unstructured":"Zhang J, Patel JM, Wemyss-Holden SA, et al. Giant pheochromocytoma: a case report and review of the literature. Can Urol Assoc J. 2015;9(7-8):E559-E562.","journal-title":"Can Urol Assoc J"},{"key":"e_1_3_3_13_2","article-title":"Diagnostic and surgical challenges of a giant pheochromocytoma in a resource-limited setting","volume":"99","author":"Lal CK","year":"2023","unstructured":"Lal CK, Vaidya S, Shah S, et al. Diagnostic and surgical challenges of a giant pheochromocytoma in a resource-limited setting. Endocr Abstr. 2023;99:P10.","journal-title":"Endocr Abstr"},{"key":"e_1_3_3_14_2","volume-title":"StatPearls","author":"Gupta PK","year":"2025","unstructured":"Gupta PK, Marwaha B. Pheochromocytoma. In: StatPearls (Internet). 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