{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:20:07Z","timestamp":1783657207177,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Wellens\u2019 syndrome is characterized by a distinct electrocardiographic pattern, most notably biphasic or deeply inverted T waves in the anterior precordial leads, particularly V2 and V3. These findings typically reflect transient myocardial ischemia resulting from critical stenosis of the proximal left anterior descending (LAD) artery. They are often a warning sign of an impending anterior wall myocardial infarction. However, conditions such as pseudo-Wellens\u2019 syndrome can exhibit similar electrocardiogram (ECG) changes without LAD occlusion. In this case report, we describe a 71-year-old woman who presented with chest discomfort and dyspnea and was ultimately diagnosed with sepsis-induced cardiomyopathy, which produced ECG changes mimicking Wellens\u2019 syndrome despite the absence of coronary artery disease; cardiac catheterization found no significant coronary pathology. The diagnosis was determined to be stress-induced cardiomyopathy resulting from sepsis. This report highlights the importance of distinguishing between ischemic and nonischemic causes of similar ECG patterns. It emphasizes the necessity for careful diagnosis and management, particularly in complex situations like sepsis.<\/jats:p>","DOI":"10.1177\/23247096251374515","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:06:24Z","timestamp":1756793184000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["When the ECG Deceives: A Case of Pseudo-Wellens\u2019 Syndrome in the Setting of Stress-Induced Cardiomyopathy"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7098-8538","authenticated-orcid":false,"given":"Rouba","family":"Isshak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Janiec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2592-4927","authenticated-orcid":false,"given":"Sacide S.","family":"Ozgur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezin","family":"Shamoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Elkattawy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez","family":"Shamoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90480-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.12890\/2024_004525"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90742-4"},{"key":"e_1_3_3_5_2","article-title":"Non-atherosclerotic myocardial infarction with a presentation of Wellens syndrome","volume":"12","author":"Jamshaid MB","year":"2020","unstructured":"Jamshaid MB, Shahzad A, Iqbal P, et al. Non-atherosclerotic myocardial infarction with a presentation of Wellens syndrome. Cureus. 2020;12:e9116.","journal-title":"Cureus"},{"key":"e_1_3_3_6_2","article-title":"Wellens\u2019 syndrome: a sign of impending myocardial infarction","volume":"14","author":"Mathew R","year":"2022","unstructured":"Mathew R, Zhang Y, Izzo C, Reddy P. Wellens\u2019 syndrome: a sign of impending myocardial infarction. Cureus. 2022;14:e26084.","journal-title":"Cureus"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14758"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02756-y"},{"key":"e_1_3_3_9_2","first-page":"68","article-title":"Myocardial bridge of the left anterior descending artery causing pseudo-Wellens\u2019 syndrome: a report of two cases","volume":"7","author":"Guha D","year":"2023","unstructured":"Guha D, Mendoza-Garcia FC, Millen KM, et al. Myocardial bridge of the left anterior descending artery causing pseudo-Wellens\u2019 syndrome: a report of two cases. Clin Pract Cases Emerg Med. 2023;7:68-72.","journal-title":"Clin Pract Cases Emerg Med"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(22)04434-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3892\/mi.2023.78"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.916623"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.035"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2043-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-015-0112-5"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096251374515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096251374515","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096251374515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:45Z","timestamp":1777449885000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096251374515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":14,"alternative-id":["10.1177\/23247096251374515"],"URL":"https:\/\/doi.org\/10.1177\/23247096251374515","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"article-number":"23247096251374515"}}