{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:53:29Z","timestamp":1777672409685,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Brookdale Hospital Research Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder characterized by cytopenia and autoimmune manifestations. While cytopenia and rheumatoid arthritis (RA) are common, transfusion-dependent anemia (TDA) without RA or other autoimmune disease is less frequently observed. We present a 79-year-old male with T-cell LGL leukemia, exhibiting isolated TDA without an autoimmune disease. Anemia remained refractory to erythropoietin and methotrexate, requiring transfusions, but showed a response to cyclophosphamide after 3\u2009months of therapy. This case highlights an uncommon presentation of LGL leukemia, emphasizing the importance of considering LGL leukemia in the differential diagnosis of TDA.<\/jats:p>","DOI":"10.1177\/23247096251385340","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:21:56Z","timestamp":1761913316000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["T-Cell Large Granular Lymphocytic Leukemia Presenting as Isolated Transfusion-Dependent Anemia Without Autoimmune Disease: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"given":"Shengmin","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amulya","family":"Bellamkonda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-6645","authenticated-orcid":false,"given":"Jen C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018481"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-3-263"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2024000539"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00632-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-692590"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.2.483"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.1.256"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1620.1620"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00136.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0895-3"},{"issue":"1","key":"e_1_3_2_14_2","article-title":"The Cosmos Collaborative: a vendor-facilitated electronic health record data aggregation platform","volume":"5","author":"Tarabichi Y","year":"2021","unstructured":"Tarabichi Y, Frees A, Honeywell S, et al. 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