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Patients with localized amyloidosis do not develop systemic diseases such as cardiac, renal, hepatic, or nerve involvement. Typically, the localized disease is managed by surgical resection, while the systemic disease is treated with a combination chemotherapy and immunotherapy. However, some patients can have challenging clinical presentations, delaying diagnosis and organ dysfunction, and they might require systemic therapeutic intervention. There is a significant paucity of knowledge and data regarding clinical manifestations and the course of localized amyloidosis in various organs, and management can also be challenging. It is crucial to appropriately balance effective therapy with patient safety as treatment can lead to toxicity. Here, we discuss a series of patients who were presented with localized amyloidosis and one of whom needed systemic therapy.<\/jats:p>","DOI":"10.1177\/23247096251400068","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:15:11Z","timestamp":1766056511000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Story of Localized Amyloidosis: Something Old and Something New \u2013 A Case Series"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0331-892X","authenticated-orcid":false,"given":"Pranati","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine, Loma Linda University Health, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol D.","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine, Loma Linda University, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Jin Jeon","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Loma Linda University Health, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9038-8752","authenticated-orcid":false,"given":"Aren","family":"Dermarderosian","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-5560","authenticated-orcid":false,"given":"Derek","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loma Linda University Health, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Latif","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loma Linda University Health, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Akhtari","sequence":"additional","affiliation":[{"name":"Division of Transplant, Cellular Therapy, and Hematologic Malignancies, Loma Linda University Health, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023144"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-629790"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2304088"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.02.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.489187"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.100"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1304649"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0046-2017"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1309\/3GECPW2402F6V8EK"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813490896"},{"key":"e_1_3_3_15_2","first-page":"9098201","article-title":"Hemodialysis-related amyloidosis in the tongue","volume":"2022","author":"Nakamura S","year":"2022","unstructured":"Nakamura S, Yamada M, Iijima Y, et al. 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