{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:58:33Z","timestamp":1792979913681,"version":"4.5.0"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>May\u2013Thurner syndrome (MTS) is a developmental anatomical variant in which the right common iliac artery compresses the left common iliac vein against the underlying lumbar vertebral body. This compression leads to endothelial injury, venous stasis, and progressive luminal narrowing, significantly increasing the risk of left-sided iliofemoral deep vein thrombosis (DVT). Combined oral contraceptives containing ethinyl estradiol are known to increase the risk of DVT, particularly during the initial months of use or during dose changes, with thrombotic risk persisting for up to 10 to 12\u2009weeks after discontinuation. We present the case of a 34-year-old previously healthy female with no significant past medical history who presented with left leg swelling and lower abdominal discomfort. She had intermittently used a combined estrogen-containing oral contraceptive pill, discontinued 2\u2009weeks prior to presentation. Imaging confirmed extensive DVT, and computed tomography venography revealed classic features of MTS, with compression of the left common iliac vein by the right common iliac artery. This case underscores the importance of evaluating structural etiologies in young patients and emphasizes the synergistic risk between hormonal and anatomical factors in precipitating a DVT. Timely diagnosis and targeted management were essential to achieving a favorable outcome.<\/jats:p>","DOI":"10.1177\/23247096251407818","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:14:57Z","timestamp":1766481297000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Vein 2 Worlds Collide: May\u2013Thurner Syndrome and Oral Contraceptive Pill Use Precipitating Deep Vein Thrombosis in an Otherwise Healthy Patient"],"prefix":"10.1177","volume":"13","author":[{"given":"Ishani","family":"Deshpande","sequence":"first","affiliation":[{"name":"Western University of Health Sciences, Long Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9846-1760","authenticated-orcid":false,"given":"Ananya","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Western University of Health Sciences, Long Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar Reddy","family":"Kalluru","sequence":"additional","affiliation":[{"name":"Internal Medicine, West Anaheim Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Vattadi","sequence":"additional","affiliation":[{"name":"Internal Medicine, West Anaheim Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Topacio","sequence":"additional","affiliation":[{"name":"Internal Medicine, West Anaheim Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61796-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61304-9"},{"key":"e_1_3_2_4_2","first-page":"231","article-title":"May-Thurner syndrome: a not-so-uncommon cause of a common condition","volume":"25","author":"Peters M","year":"2012","unstructured":"Peters M, Syed RK, Katz M, et al. May-Thurner syndrome: a not-so-uncommon cause of a common condition. Proc (Bayl Univ Med Cent). 2012;25:231-233.","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0959-6230"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.10.14"},{"key":"e_1_3_2_7_2","first-page":"1","article-title":"Current diagnostic and therapeutic approaches in May-Thurner syndrome in children and adolescents","volume":"44","author":"Cuntz J","year":"2024","unstructured":"Cuntz J, M\u00fcller M, Thelen M, et al. Current diagnostic and therapeutic approaches in May-Thurner syndrome in children and adolescents. Haemostaseologie. 2024;44:1-8.","journal-title":"Haemostaseologie"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.3415"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.05.001"},{"key":"e_1_3_2_10_2","first-page":"327","article-title":"The venous thrombotic risk of oral contraceptives and the persistence of risk after discontinuation","volume":"8","author":"van Hylckama Vlieg A","year":"2010","unstructured":"van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, et al. The venous thrombotic risk of oral contraceptives and the persistence of risk after discontinuation. 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