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She was dependent on total parenteral nutrition (TPN) following ileocecectomy for Degos-related gastrointestinal complications and had recently transitioned from intravenous (IV) to oral thiamine supplementation. Although central nervous system involvement of Degos was initially suspected, magnetic resonance imaging findings, low thiamine levels, and rapid improvement with IV thiamine confirmed Wernicke\u2019s encephalopathy. This case highlights the importance of recognizing nutritional deficiencies in TPN-dependent patients with neurologic symptoms, even in the context of a rare underlying disease.<\/jats:p>","DOI":"10.1177\/23247096261425185","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:09:56Z","timestamp":1771582196000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Wernicke Encephalopathy Associated with Malabsorption in Degos Disease"],"prefix":"10.1177","volume":"14","author":[{"given":"Anna","family":"Ilyasova","sequence":"first","affiliation":[{"name":"University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Eusebio","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-5886","authenticated-orcid":false,"given":"Lauren","family":"Raff","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery Medicine, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-858X","authenticated-orcid":false,"given":"Evan","family":"Raff","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-020-02514-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.05.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-10"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1164-5"},{"issue":"3","key":"e_1_3_2_6_2","first-page":"646","article-title":"Nervous system involvement in Degos disease","volume":"26","author":"Amato C","year":"2005","unstructured":"Amato C, Ferri R, Elia M, et al. 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