{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:53:59Z","timestamp":1777672439935,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Low platelet count is rarely caused by inherited thrombocytopenia. May\u2013Hegglin anomaly is an uncommon condition that falls under the umbrella of familial thrombocytopenia. The condition is under-reported in Saudi Arabia; therefore, we report the current case. This is a 24-year-old Saudi lady, presented to the emergency room with vaginal bleeding. No bleeding occurred at any other sites. She has a positive family history of thrombocytopenia among her father and 2 of her siblings. Her platelet count was 16\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/\u00b5L with normal other blood count as well as renal and liver panels. She was admitted to the regular bed for investigation as sever thrombocytopenia with suspicion of either familial or immune thrombocytopenia. Further studies showed normal hemostatic, virology, and connective tissue disease markers. Peripheral blood film showed low platelet distribution with occasional large\/giant platelets and basophilic inclusion bodies in some neutrophils (Dohle body-like). A picture suggestive of May\u2013Hegglin related thrombocytopenia that was confirmed by the presence of a positive myosin heavy chain 9 (MYH9) gene mutation. In conclusion, there are many difficulties in diagnosing and treating May\u2013Hegglin disorders in females of reproductive age. More research and guidelines are needed to manage inherited thrombocytopenia before and throughout pregnancy.\n                  <\/jats:p>","DOI":"10.1177\/23247096261425195","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:21:46Z","timestamp":1771672906000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Thrombocytopenia Caused by a May\u2013Hegglin Anomaly in a Young Saudi Female"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-5769","authenticated-orcid":false,"given":"Rehab Y.","family":"Al-Ansari","sequence":"first","affiliation":[{"name":"Internal Medicine Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"},{"name":"Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan Rashed","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan Mansour","family":"Aljurbua","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mohammed","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Laboratory Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad F.","family":"Abdellatif","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawaf","family":"Zakary","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, KFMMC, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"issue":"14","key":"e_1_3_3_2_2","first-page":"1924","article-title":"Managing thrombocytopenia in the clinic: a practical guide","volume":"137","author":"Kuter DJ.","year":"2021","unstructured":"Kuter DJ. Managing thrombocytopenia in the clinic: a practical guide. Blood. 2021;137(14):1924\u20111935.","journal-title":"Blood"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14547"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036735"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102552"},{"key":"e_1_3_3_6_2","volume-title":"May\u2013Hegglin Anomaly","author":"Untanu RV","year":"2021","unstructured":"Untanu RV, Vajpayee N. May\u2013Hegglin Anomaly. StatPearls; 2021."},{"issue":"2","key":"e_1_3_3_7_2","first-page":"111","article-title":"A rare familial thrombocytopenia: May\u2011Hegglin anomaly report of two cases and review of the literature","volume":"23","author":"G\u00fclen H","year":"2006","unstructured":"G\u00fclen H, Erbay A, Kazanc\u0131 E, Vergin C. A rare familial thrombocytopenia: May\u2011Hegglin anomaly report of two cases and review of the literature. Turk J Haematol. 2006;23(2):111\u2011114.","journal-title":"Turk J Haematol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/kleuhsj.kleuhsj_567_22"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017735"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2012.10.009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-024-00610-w"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010132"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081968"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8304"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2016.08.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320335"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-06-0424"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000050960.48774.17"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-071589"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32835fad03"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096261425195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096261425195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096261425195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:56Z","timestamp":1777449896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096261425195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":20,"alternative-id":["10.1177\/23247096261425195"],"URL":"https:\/\/doi.org\/10.1177\/23247096261425195","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"article-number":"23247096261425195"}}