{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:43:51Z","timestamp":1782981831705,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Melanoma is an aggressive malignancy with a high propensity for metastasis; however, clinically apparent involvement of the gastrointestinal tract is uncommon. We report a case of metastatic melanoma involving the stomach that presented as gastrointestinal bleeding shortly after initial diagnosis. A patient with recently diagnosed melanoma with nodal metastasis presented with melena and symptomatic anemia. Esophagogastroduodenoscopy revealed multiple gastric mucosal lesions that were notably amelanotic, lacking the characteristic pigmentation typically associated with melanoma. Histopathological and immunohistochemical evaluation confirmed metastatic melanoma, and imaging findings were concerning for advanced disease. The presence of pneumatosis raised suspicion for mucosal compromise and possible early perforation, highlighting the potential severity of gastrointestinal involvement. Gastrointestinal metastases from melanoma are often clinically silent and may present with nonspecific symptoms, leading to delayed diagnosis. This case is notable for early symptomatic presentation and the presence of amelanotic lesions, which may be easily overlooked during endoscopic evaluation. The absence of pigmentation can pose a diagnostic challenge and requires a high index of suspicion in patients with a history of melanoma. Early endoscopic evaluation and tissue diagnosis are essential for timely recognition and management. Clinicians should maintain a high index of suspicion for gastrointestinal metastases in melanoma patients presenting with unexplained anemia or bleeding, even in the absence of classic endoscopic features.<\/jats:p>","DOI":"10.1177\/23247096261465530","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:10:32Z","timestamp":1782727832000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Amelanotic Gastric Metastases From Melanoma Presenting as Gastrointestinal Bleeding Shortly After Diagnosis: A Case Report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9803-7950","authenticated-orcid":false,"given":"Yagnapriya","family":"Chirrareddy","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-345X","authenticated-orcid":false,"given":"Ritwik","family":"Dey","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virali","family":"Gulla","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-0389","authenticated-orcid":false,"given":"Manas","family":"Pustake","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0461-6312","authenticated-orcid":false,"given":"Shivangini","family":"Duggal","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Jaladi","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus A.","family":"Gomez","sequence":"additional","affiliation":[{"name":"University Medical Center El Paso"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-015-0485-6"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/647684"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goaf107"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3402\/jchimp.v6.31972"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.434"},{"key":"e_1_3_6_7_2","first-page":"63","article-title":"Epidemiology of melanoma","volume":"9","author":"Saginala K","year":"2021","unstructured":"Saginala K, Barsouk A, Aluru JS, Rawla P. Epidemiology of melanoma. Med Sci (Basel). 2021;9:63.","journal-title":"Med Sci (Basel)"},{"key":"e_1_3_6_8_2","unstructured":"National Cancer Institute. Cancer stat facts: melanoma of the skin. 2025. SEER [Internet][cited 2026 Jan 31]. Available from. https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html"},{"key":"e_1_3_6_9_2","unstructured":"National Cancer Institute. Annual report to the nation 2025. 2025. SEER [Internet] [cited 2026 Jan 31]. Available from. https:\/\/seer.cancer.gov\/report_to_nation\/"},{"key":"e_1_3_6_10_2","volume-title":"Cancer statistics center","author":"American Cancer Society","year":"2025","unstructured":"American Cancer Society. Cancer statistics center. American Cancer Society; 2025. [Internet][cited 2026 Jan 31]. Available from. https:\/\/cancerstatisticscenter.cancer.org\/"},{"key":"e_1_3_6_11_2","volume-title":"Metastatic melanoma. 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