{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:18:20Z","timestamp":1793384300336,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Case Western Reserve University Clinical and Translational Science Collaborative","award":["4UL1TR000439"],"award-info":[{"award-number":["4UL1TR000439"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["LGBT Health"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study compared the prevalence of hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorder (HSD) between transgender and gender-diverse (TGD) individuals and cisgender individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis using a large electronic health record database spanning 2004\u20132024. TGD individuals were identified using International Classification of Diseases, Tenth Revision codes related to gender identity and stratified by hormone therapy status. Cisgender comparison groups were defined by the absence of gender identity diagnoses and hormone therapy exposure. Prevalence odds ratios (ORs) with 95% confidence intervals were calculated to compare hEDS and HSD diagnoses between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>TGD individuals demonstrated a significantly higher prevalence of hEDS and HSD than cisgender individuals (OR: 18.45). The prevalence among TGD individuals assigned female at birth was 2.62%, and among those assigned male at birth, 1.00%, compared with 0.16% and 0.04% in cisgender females and males, respectively. Hormone therapy status was not associated with significant differences in prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings indicate a substantially increased burden of hypermobility-related disorders among TGD individuals. Enhanced clinical recognition and multidisciplinary management strategies are needed to address the unique health care challenges faced by this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23258292251382250","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:24:58Z","timestamp":1758648298000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Hypermobile Ehlers-Danlos Syndrome in Transgender and Gender Diverse Individuals: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0650-3349","authenticated-orcid":false,"given":"Tomasz","family":"Tabernacki","sequence":"first","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"McLachlan","sequence":"additional","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5982-3931","authenticated-orcid":false,"given":"Matthew","family":"Loria","sequence":"additional","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Gupta","sequence":"additional","affiliation":[{"name":"Urology Institute, University Hospitals, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagata","family":"Banik","sequence":"additional","affiliation":[{"name":"St. Bonaventure University, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirtishri","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."},{"name":"Urology Institute, University Hospitals, Cleveland, Ohio, USA."},{"name":"Department of Urology, MetroHealth Cleveland Medical Center, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"McNamara","sequence":"additional","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."},{"name":"Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31538"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31425"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmv026"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X221112841"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X231212081"},{"key":"e_1_3_4_8_2","volume-title":"The Voice of 12,000 Patients: Experiences and Expectations of Rare Disease Patients on Diagnosis and Care in Europe","author":"EURORDIS","year":"2009","unstructured":"EURORDIS. The Voice of 12,000 Patients: Experiences and Expectations of Rare Disease Patients on Diagnosis and Care in Europe. EURORDIS: Paris, France; 2009."},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031365"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0922-6"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew478"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2021.89"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121221146074"},{"key":"e_1_3_4_14_2","unstructured":"Stelzer A. \u201cNot a reliable witness to my own body\u201d: Women trans and non-binary people with Ehlers-Danlos syndromes and their encounters with power and gender bias in the access of medicine [master\u2019s thesis]. \u00c5s Norway: Norwegian University of Life Sciences; 2023."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031866"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.4725"},{"key":"e_1_3_4_17_2","unstructured":"TriNetX. TriNetX LLC: Cambridge MA. Available from: https:\/\/trinetx.com\/ [Last accessed: December20 2024]."},{"key":"e_1_3_4_18_2","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10)","author":"World Health Organization","year":"2016","unstructured":"World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). 5th ed. World Health Organization: Geneva, Switzerland; 2016.","edition":"5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jsxmed\/qdac033"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040928"},{"key":"e_1_3_4_21_2","unstructured":"Dean A. OpenEpi: Open Source Epidemiologic Statistics for Public Health. 2013. Atlanta GA: Emory University. 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