{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:11:16Z","timestamp":1777853476686,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare quantiferon-TB gold \u201cin tube\u201d (QFT-IT) with the conventional tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI) in HIV-infected adults in a setting highly endemic for tuberculosis with BCG vaccinated population in Bangalore, Karnataka, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>The study population (100 BCG-vaccinated adults) was divided into 4 groups: HIV patients with TB patient contact, HIV patients with past history of TB, TB patients (positive control), and healthy volunteers (negative control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall agreement between TST and QFT-IT was 52.4% (\u03ba = 0.22). Increasing the TST cutoff value from 5 mm to 10 mm among HIV-positive groups resulted in better agreement 62.5% in Group 1 and 81.2% in Group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>In a setting with high TB prevalence, the TST gives increased false positives in HIV-positive groups if 5 mm is used as the cutoff value. This could be minimized by increasing the cutoff to 10 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The 2-step approach (initial testing of all cases with TST and confirmation of only those positive in TST by testing with QFT-IT) will be economical and help in treating LTBI cases in lower middle income countries like India.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325957412469687","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T21:32:36Z","timestamp":1363123956000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["The Performance of Quantiferon-TB Gold in-Tube (QFT-IT) Test Compared to Tuberculin Skin Test (TST) in Detecting Latent Tuberculosis Infection (LTBI) in the Presence of HIV Coinfection in a High TB-Burden Area with BCG-Vaccinated Population"],"prefix":"10.1177","volume":"13","author":[{"given":"Pratibha Malini","family":"James","sequence":"first","affiliation":[{"name":"Kempegowda Institute of Medical Sciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feroze Ahmed","family":"Ganaie","sequence":"additional","affiliation":[{"name":"Chromus Biotech, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikumar Lingegowda","family":"Kadahalli","sequence":"additional","affiliation":[{"name":"Kempegowda Institute of Medical Sciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"bibr1-2325957412469687","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.035329"},{"key":"bibr2-2325957412469687","unstructured":"World Health Organization. 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