{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:56:44Z","timestamp":1792022204977,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to describe the prevalence and pattern of lipid abnormalities among antiretroviral therapy (ART)-naive HIV patients, understand if there is any relationship to virologic and immunologic status, and discuss the implications for care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a cross-sectional study in which baseline demographic, clinical, and laboratory data of all ART-naive HIV-infected individuals recruited into the adult ARV clinic, University College Hospital, Ibadan, between January and December 2006, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 1316 ART-naive HIV-infected persons were recruited in the period. Females subjects and participants aged \u226635 years accounted for 67.1% and 57.7% of all participants, respectively. At least 1 abnormal lipid fraction was seen in 73.3% of participants. It was observed that in 11.5% participants the total cholesterol (TC) was \u22675.2 mmol\/L, in 2.7% the low-density lipoprotein cholesterol (LDL)-C was &gt;4.1 mmol\/L in 56.5% the high-density lipoprotein cholesterol (HDL)-C was &lt;1.0 mmol\/L, and in 27.6% the triglyceride (TG) was &gt;1.7 mmol\/L. The TC, LDL-C, and HDL-C were all significantly positively correlated with CD4 counts and negatively correlated with viral load. On the contrary, the TG levels were negatively correlated with CD4 counts and positively correlated with viral load. Multivariate linear analysis showed a significant relationship between all the lipid parameters and viral load. CD4 counts were only significantly associated with TC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A significant burden of dyslipidemia exists among ART-naive HIV-infected persons. Low HDL-C was the most frequently observed abnormality. The abnormalities related more with viral load levels than with CD4 counts. Dyslipidemia screening should be done in ART-naive HIV-infected persons. Simple healthy lifestyle changes should be emphasized, with other care given to those with the disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325957414555227","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T02:47:36Z","timestamp":1413859656000},"page":"355-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Dyslipidemia in ART-Naive HIV-Infected Persons in Nigeria\u2014Implications for Care"],"prefix":"10.1177","volume":"14","author":[{"given":"Modupe Akinrele","family":"Kuti","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubukola Adeponle","family":"Adesina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin Alaba","family":"Awolude","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babatunde Oluwatosin","family":"Ogunbosi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Adetona","family":"Fayemiwo","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua Odunayo","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adedotun Adeyinka","family":"Adetunji","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achiaka Emmanuelle","family":"Irabor","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina Njideka","family":"Odaibo","sequence":"additional","affiliation":[{"name":"Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okonkwo","family":"Prosper","sequence":"additional","affiliation":[{"name":"AIDS Prevention Iniative in Nigeria (APIN), Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babafemi Olapoju","family":"Taiwo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Kanki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Folorunso","family":"Adewole","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"bibr1-2325957414555227","volume-title":"Global HIV\/AIDS Response: Epidemic Update and Health Sector Progress Towards Universal Access: Progress Report 2011","author":"World Health Organization, UNAIDS, 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