{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:11:38Z","timestamp":1777853498512,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To estimate health care costs associated with medical events identified as antiretroviral therapy (ART)-attributable adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>During September 2006 to June 2012, adults with \u22651 HIV International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code (042\/V08), \u22651 claim for ART prescription (March 2007-June 2011; index date), and continuous health plan enrollment for \u22656 months pre- and \u226512 months postindex were included (IMS\u2019 PharMetrics Plus Health Plan Claims Database). Patients with events of interest\/ART claim during preindex period or with pregnancy\/hepatitis C virus diagnosis\/hepatitis B virus\/cancer\/tuberculosis during the study period were excluded. Postindex medical events were defined as first diagnosis code of event with ART claim \u226460 days prior to start of the event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Differences in median total all-cause health care costs observed for diabetes\/insulin resistance management (US$14 547 median all-cause health care costs during time periods identified as diabetes\/insulin resistance medical events versus US$11 237 without diabetes\/insulin resistance events; P = .0021), lipid disorders (US$12 825 versus US$10 033; P = .0004), and renal disorders (US$1389 versus US$0; P &lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion\/Conclusion:<\/jats:title>\n                    <jats:p>Health care costs of ART AEs should be key consideration for payers\/providers in HIV management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325957415594883","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T23:14:27Z","timestamp":1438211667000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Economic Burden of HIV Antiretroviral Therapy Adverse Events in the United States"],"prefix":"10.1177","volume":"15","author":[{"given":"Mitch","family":"Dekoven","sequence":"first","affiliation":[{"name":"IMS Health, Fairfax, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Makin","sequence":"additional","affiliation":[{"name":"IMS Health, Fairfax, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Slaff","sequence":"additional","affiliation":[{"name":"Yoh Services LLC, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Marcus","sequence":"additional","affiliation":[{"name":"IMS Health, Fairfax, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Maiese","sequence":"additional","affiliation":[{"name":"Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"bibr1-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.5.520"},{"key":"bibr2-2325957415594883","unstructured":"Centers for Disease Control and Prevention. HIV Surveillance Report, 2010, vol. 22. Web site. http:\/\/www.cdc.gov\/hiv\/pdf\/statistics_surveillance_report_vol_22.pdf. Published March 2012. Accessed August 21, 2013."},{"key":"bibr3-2325957415594883","unstructured":"Centers for Disease Control and Prevention. Estimated HIV incidence among adults and adolescents in the United States, 2007\u20132010. HIV Surveillance Supplemental Report 2012;17(No. 4). Web site. http:\/\/www.cdc.gov\/hiv\/pdf\/statistics_hssr_vol_17_no_4.pdf."},{"key":"bibr4-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.23.2220"},{"key":"bibr5-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199910010-00017"},{"key":"bibr6-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"bibr7-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.712667"},{"key":"bibr8-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.432"},{"key":"bibr9-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181a4f00d"},{"key":"bibr10-2325957415594883","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200312010-00008"},{"key":"bibr11-2325957415594883","unstructured":"Centers for Disease Control and Prevention. National Center for HIV\/AIDS, Viral Hepatitis, STD and TB Prevention. Web site. http:\/\/www.cdc.gov\/nchhstp\/. 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