{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:13Z","timestamp":1777853173170,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>\n                    Current guidelines suggest that HIV-infected patients should receive chemoprophylaxis against Pneumocystis jirovecii pneumonia (PJP) if they have a cluster determinant 4 (CD4) count &lt;200 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    or oropharyngeal candidiasis. Persons with CD4 percentage (CD4%) below 14% should also be considered for prophylaxis. Discordance between CD4 count and CD4% occurs in 16% to 25% of HIV-infected patients. Provider compliance with current PJP prophylaxis guidelines when such discordance is present was assessed. Electronic medical records of 429 HIV-infected individuals who had CD4 count and CD4% measured at our clinic were reviewed. CD4 count and percentage discordance was seen in 57 (13%) of 429. Patients with CD4 count &gt;200 but CD4% &lt;14 were significantly less likely to be prescribed PJP prophylaxis compared with those who had CD4 count &lt;200 and CD4% &gt;14 (29% versus 86%; odds ratio = 0.064, 95% confidence interval: 0.0168-0.2436; P &lt; .0001). We emphasize monitoring both the absolute CD4 count and percentage to appropriately guide PJP primary and secondary prophylaxis.\n                  <\/jats:p>","DOI":"10.1177\/2325958218759199","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T03:49:36Z","timestamp":1520999376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Absolute CD4 Count and Percentage Discordance on Pneumocystis Jirovecii Pneumonia Prophylaxis in HIV-Infected Patients"],"prefix":"10.1177","volume":"17","author":[{"given":"Henry","family":"Anyimadu","sequence":"first","affiliation":[{"name":"Hospital of Central Connecticut, New Britain, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Pingili","sequence":"additional","affiliation":[{"name":"Columbia University Affiliated with Harlem Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vel","family":"Sivapalan","sequence":"additional","affiliation":[{"name":"Columbia University Affiliated with Harlem Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Hirsch-Moverman","sequence":"additional","affiliation":[{"name":"Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Mannheimer","sequence":"additional","affiliation":[{"name":"Columbia University Affiliated with Harlem Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"bibr1-2325958218759199","unstructured":"Masur H. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. http:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adult_oi.pdf. 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Vital signs: HIV Diagnosis, Care and Treatment Among Persons Living with HIV\u2013United States, 2011. MMWR Morb Mortal Wkly Rep. 2014; 63(47):1113\u20131117. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25426654."},{"key":"bibr28-2325958218759199","unstructured":"Denis B, Guiguet M, Gregoire G, Pneumocystis jirovecii pneumonia (PCP) in HIV infected patients in France in the combined antiretroviral therapy (cART) era is associated with late presentation or poor adherence. Paper presented at: 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 2013; Denver, CO. Abstract H-1260. http:\/\/www.natap.org\/2013\/ICAAC\/ICAAC_79.htm. 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