{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:12Z","timestamp":1777853172601,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC\/TDF) is undergoing rapid scale-up in the United States. While FTC\/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC\/TDF has not been previously described. We report the case of a 35-year-old patient who began FTC\/TDF PrEP and developed acute trigeminal neuralgia. The neurologic symptoms resolved after treatment discontinuation and recurred upon rechallenge, resulting in permanent discontinuation of PrEP treatment.<\/jats:p>","DOI":"10.1177\/2325958218760846","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T03:49:36Z","timestamp":1520999376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine\/Tenofovir for HIV Pre-Exposure Prophylaxis"],"prefix":"10.1177","volume":"17","author":[{"given":"Loraine","family":"Van Slyke","sequence":"first","affiliation":[{"name":"APEX Research\/Family Medicine, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Scott","sequence":"additional","affiliation":[{"name":"APEX Research\/Family Medicine, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"bibr1-2325958218760846","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"bibr2-2325958218760846","unstructured":"Centers for Disease Control and Prevention (CDC). Preexposure Prophylaxis for the Prevention of HIV Infection in the United States\u20142014: A Clinical Practice Guideline. 2014. https:\/\/www.cdc.gov\/hiv\/pdf\/prepguidelines2014.pdf. Accessed February 15, 2018."},{"key":"bibr3-2325958218760846","unstructured":"World Health Organization. Guidance on oral pre-exposure prophylaxis (PrEP) for serodiscordant couples, men, and transgender women who have sex with men at high risk of HIV. http:\/\/www.who.int\/hiv\/pub\/guidance_prep\/en\/. 2012. 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