{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:19Z","timestamp":1777853179051,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To examine the risk of hypomagnesemia of HIV-positive patients adherent to proton pump inhibitors (PPIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cohort study utilizing the Veterans Affairs Informatics and Computing Infrastructure was conducted on patients with (1) a complete antiretroviral therapy, (2) a serum magnesium measure during the study period, and (3) adherent to PPIs. Statistical analyses evaluated baseline characteristics between cohorts and a Cox proportional hazards model evaluating the association of hypomagnesemia while adjusting for baseline covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 6047 patients met the study inclusion criteria, 329 patients in the PPI cohort and 5718 patients in the non-PPI cohort. The stratified Cox proportional hazards model results revealed that the risk of hypomagnesemia for the PPI cohort is 3.16 times higher compared to the non-PPI cohort (adjusted hazard ratio = 3.16, 95% confidence interval = 2.56-3.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Proton pump inhibitors medication usage in HIV-positive patients is associated with a higher risk of hypomagnesemia compared to non-PPI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325958218821652","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T03:49:13Z","timestamp":1548128953000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia in a National Cohort of Veteran Patients with HIV"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-6178","authenticated-orcid":false,"given":"S. Scott","family":"Sutton","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina, College of Pharmacy, Columbia, SC, USA"},{"name":"Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Magagnoli","sequence":"additional","affiliation":[{"name":"Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Cummings","sequence":"additional","affiliation":[{"name":"WJB Dorn Veterans Affairs Medical Center, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0506-5500","authenticated-orcid":false,"given":"James W.","family":"Hardin","sequence":"additional","affiliation":[{"name":"Biostatistics Division, Department of Epidemiology & Biostatistics, University of South Carolina, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"bibr1-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.462"},{"key":"bibr2-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.7927"},{"key":"bibr3-2325958218821652","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2015.1094088"},{"key":"bibr4-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112558"},{"key":"bibr5-2325958218821652","first-page":"2015","volume":"951768","author":"Janett S","year":"2015","journal-title":"Gastroenterol Res Pract"},{"key":"bibr6-2325958218821652","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2016.0284"},{"issue":"11","key":"bibr7-2325958218821652","first-page":"21689","volume":"8","author":"Erdem E","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr8-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500002"},{"key":"bibr9-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768986"},{"key":"bibr10-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"bibr11-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281532b31"},{"key":"bibr12-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000643"},{"key":"bibr13-2325958218821652","unstructured":"Therneau TM. A package for survival analysis in\n                      R. Survival (Lond)\n                      . 2015. http:\/\/cran.r-project.org\/package=survival. Accessed November 2017."},{"key":"bibr14-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc066308"},{"key":"bibr15-2325958218821652","first-page":"169","volume":"67","author":"Kuipers MT","year":"2009","journal-title":"Netherland J Med"},{"key":"bibr16-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0139-9"},{"key":"bibr17-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.452"},{"key":"bibr18-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31829c4c71"},{"key":"bibr19-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001736"},{"key":"bibr20-2325958218821652","doi-asserted-by":"crossref","unstructured":"Luk CP, Parsons R, Lee YP, Hughes JD. Proton pump inhibitor-associated hypomagnesemia: what Do FDA data tell us? Ann Pharmacother. 2013;47(6):773. https:\/\/auth.lib.unc.edu\/ezproxy_auth.php?%20url=http:\/\/search.ebscohost.com\/login.aspx?%20direct=true&db=ipa&AN=50-15425&site=ehost-live&scope=site.","DOI":"10.1345\/aph.1R556"},{"key":"bibr21-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05201.x"},{"key":"bibr22-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015735"},{"key":"bibr23-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3224"},{"key":"bibr24-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1905-7"},{"key":"bibr25-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138881"},{"key":"bibr26-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3615-y"},{"key":"bibr27-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0119"},{"key":"bibr28-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2007.00456.x"},{"key":"bibr29-2325958218821652","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq167"}],"container-title":["Journal of the International Association of Providers of AIDS Care (JIAPAC)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218821652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2325958218821652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218821652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:20Z","timestamp":1777502960000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2325958218821652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":29,"alternative-id":["10.1177\/2325958218821652"],"URL":"https:\/\/doi.org\/10.1177\/2325958218821652","relation":{},"ISSN":["2325-9582","2325-9582"],"issn-type":[{"value":"2325-9582","type":"print"},{"value":"2325-9582","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"2325958218821652"}}