{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:25Z","timestamp":1777853185280,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>Elvitegravir\/cobicistat\/emtricitabine\/tenofovir alafenamide (E\/C\/F\/TAF) is a potent fixed-dose, once-daily regimen for HIV-1 treatment and has rare emergence of drug resistance. We report a potential drug\u2013drug interaction in 2 female patients both receiving treatment for HIV and cerebral toxoplasmosis: one case between E\/C\/F\/TAF with calcium carbonate and a second case involving leucovorin as calcium salt. Both cases resulted in rise in HIV RNA levels and emergence of M184 V mutation and resistance to elvitegravir and raltegravir. To the best of our knowledge, these 2 cases are the first reports of rapid emergence of mutation from coadministration of E\/C\/F\/TAF and calcium.<\/jats:p>","DOI":"10.1177\/2325958218821653","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T12:39:05Z","timestamp":1546951145000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["HIV Viral Rebound Due to a Possible Drug\u2013Drug Interaction between Elvitegravir\/Cobicistat\/Emtricitabine\/Tenofovir Alafenamide and Calcium-Containing Products: Report of 2 Cases"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-0922","authenticated-orcid":false,"given":"S. Lena","family":"Kang-Birken","sequence":"first","affiliation":[{"name":"Immunology Clinic, Ventura County Medical Center, Ventura, CA, USA"},{"name":"Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dena","family":"El-sayed","sequence":"additional","affiliation":[{"name":"Immunology Clinic, Ventura County Medical Center, Ventura, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Prichard","sequence":"additional","affiliation":[{"name":"Immunology Clinic, Ventura County Medical Center, Ventura, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"bibr1-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60616-X"},{"key":"bibr2-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001350"},{"key":"bibr3-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv149"},{"key":"bibr4-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.03.012"},{"key":"bibr5-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31829ecd3b"},{"key":"bibr6-2325958218821653","volume-title":"Genvoya [package insert]","author":"Gilead Sciences, Inc","year":"2015"},{"key":"bibr7-2325958218821653","doi-asserted-by":"publisher","DOI":"10.2165\/11584570-000000000-00000"},{"key":"bibr8-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.439"},{"key":"bibr9-2325958218821653","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00636-10"},{"key":"bibr10-2325958218821653","volume-title":"Leucovorin Calcium [package insert]","author":"Teva Pharmaceuticals, Inc","year":"2016"},{"key":"bibr11-2325958218821653","doi-asserted-by":"publisher","DOI":"10.18549\/PharmPract.2016.01.677"}],"container-title":["Journal of the International Association of Providers of AIDS Care (JIAPAC)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218821653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2325958218821653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218821653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:21Z","timestamp":1777502961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2325958218821653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":11,"alternative-id":["10.1177\/2325958218821653"],"URL":"https:\/\/doi.org\/10.1177\/2325958218821653","relation":{},"ISSN":["2325-9582","2325-9582"],"issn-type":[{"value":"2325-9582","type":"print"},{"value":"2325-9582","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"2325958218821653"}}