{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:17:14Z","timestamp":1787019434213,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The use of lifelong antiretroviral therapy (ART) results in increased costs of care; the ability to finance and control sustained costs of ART needs to be discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>The Southern Alberta Clinic initiated a practical cost savings approach that switched select patients from a branded ART to a less expensive generic variation. Our approach surveyed physicians and patients on their acceptance of switching and then launched a program asking patients if they would switch to generic variations for cost control purposes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our early findings found &gt;50% of patients approached agreed to switch. We found no evidence of increased risk of viral breakthrough, resistance, side effects, or displeasure with generic drugs. Measured cost savings in the first year were &gt;$1.1 million with annual projected savings of between $4.3 million and $2.6 million (in 2017 Cdn$).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our approach can provide an option for controlling costs of HIV care without compromising quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325958218822304","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T21:22:32Z","timestamp":1548278552000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Desimplification of Single Tablet Antiretroviral (ART) Regimens\u2014A Practical Cost-Savings Strategy?"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4842-2846","authenticated-orcid":false,"given":"Hartmut","family":"Krentz","sequence":"first","affiliation":[{"name":"Southern Alberta Clinic, Calgary, Canada"},{"name":"Department of Medicine, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayna","family":"Campbell","sequence":"additional","affiliation":[{"name":"Southern Alberta Clinic, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gill","sequence":"additional","affiliation":[{"name":"Southern Alberta Clinic, Calgary, Canada"},{"name":"Department of Medicine, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"bibr1-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30066-8"},{"key":"bibr2-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000243"},{"key":"bibr3-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"bibr4-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834dce6e"},{"key":"bibr5-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125018"},{"key":"bibr6-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833f3c14"},{"key":"bibr7-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283348944"},{"key":"bibr8-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv430"},{"key":"bibr9-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12097"},{"key":"bibr10-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.928589"},{"key":"bibr11-2325958218822304","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.4.19497"},{"key":"bibr12-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117214"},{"key":"bibr13-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000199"},{"key":"bibr14-2325958218822304","doi-asserted-by":"crossref","unstructured":"Engelhard EAN, Smit C, Vervoort SCJM, Patients\u2019 willingness to take multiple-tablet antiretroviral therapy regimens for treatment of HIV. Drugs\u2014real world outcomes [Internet]. Springer International Publishing. 2016;3(2):223\u2013230. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27398301%5Cnhttp:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?%20artid=PMC4914541","DOI":"10.1007\/s40801-016-0070-9"},{"key":"bibr15-2325958218822304","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-2-201301150-00002"},{"key":"bibr16-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147821"},{"key":"bibr17-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1077-7"},{"key":"bibr18-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001467"},{"key":"bibr19-2325958218822304","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12578"}],"container-title":["Journal of the International Association of Providers of AIDS Care (JIAPAC)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218822304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2325958218822304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218822304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:22Z","timestamp":1777502962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2325958218822304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":19,"alternative-id":["10.1177\/2325958218822304"],"URL":"https:\/\/doi.org\/10.1177\/2325958218822304","relation":{},"ISSN":["2325-9582","2325-9582"],"issn-type":[{"value":"2325-9582","type":"print"},{"value":"2325-9582","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"2325958218822304"}}