{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:23Z","timestamp":1777853183233,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001117","name":"amfAR, The Foundation for AIDS Research","doi-asserted-by":"publisher","award":["U01AI069907"],"award-info":[{"award-number":["U01AI069907"]}],"id":[{"id":"10.13039\/100001117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hepatitis B virus (HBV) and HIV coinfection is associated with risk of progression to chronic liver disease. We assessed liver stiffness in HBV-HIV coinfected youths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study in HBV-HIV coinfected youths aged 18 to 25 years who received a tenofovir (TDF)-containing antiretroviral therapy regimen for &gt;96 weeks. Measurements included HBV DNA level, HBV serology profiles, and transient elastography (TE). The cutoff for TE results included \u22655.9 kPa for F2-moderate fibrosis, \u22657.4 kPa for F3-severe fibrosis, and \u22659.6 kPa for F4-cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>From March to December 2016, 15 HBV-HIV coinfected youths with a median duration on TDF-containing regimens of 3.3 years were enrolled. Five (33%) youths had significant liver fibrosis, 3 with F2-moderate, 1 with F3-advanced fibrosis, and 1 with F4-cirrhosis. Other 5 without liver fibrosis had hepatitis B surface e antigen (HBsAg) and hepatitis B surface e antigen (HBeAg) loss. Higher mean alanine transaminase (ALT) was observed among the group with F2-F4 when compared to those with F0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Liver fibrosis was evidenced in HBV-HIV coinfected youths in Thailand. Transient elastography might be considered for those who do not achieve HBsAg loss or have persistent ALT elevation while on treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325958218823259","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T09:49:25Z","timestamp":1549014565000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk of Liver Fibrosis in Hepatitis B Virus and HIV Coinfected Youths Receiving Tenofovir-Containing Antiretroviral Regimen"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8187","authenticated-orcid":false,"given":"Linda","family":"Aurpibul","sequence":"first","affiliation":[{"name":"Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suparat","family":"Kanjanavanit","sequence":"additional","affiliation":[{"name":"Nakornping Hospital, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apinya","family":"Leerapun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of internal medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanyawee","family":"Puthanakit","sequence":"additional","affiliation":[{"name":"The HIV Netherlands, Australia, Thailand Research Collaboration (HIVNAT), Bangkok, Thailand"},{"name":"Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Center of Excellence in Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"bibr1-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302062"},{"key":"bibr2-2325958218823259","unstructured":"World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach\u20142nd ed. 2016. 100. http:\/\/apps.who.int\/iris\/bitstream\/10665\/208825\/1\/9789241549684_eng.pdf?%20ua=1. Accessed August 22, 2017."},{"key":"bibr3-2325958218823259","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.20.1.21426"},{"key":"bibr4-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ421"},{"key":"bibr5-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31825eb0ad"},{"key":"bibr6-2325958218823259","volume-title":"3rd International workshop on HIV Pediatric","author":"Sam S","year":"2011"},{"key":"bibr7-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181c99226"},{"key":"bibr8-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-015-0199-y"},{"key":"bibr9-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001491"},{"key":"bibr10-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069153"},{"key":"bibr11-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31836-8"},{"key":"bibr12-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.05.033"},{"key":"bibr13-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"bibr14-2325958218823259","volume-title":"Abstract # MOAB0105, 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention","author":"Sudjaritruk T","year":"2015"},{"key":"bibr15-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.2.223"},{"key":"bibr16-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ421"},{"key":"bibr17-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068152"},{"key":"bibr18-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12764"},{"key":"bibr19-2325958218823259","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12521"}],"container-title":["Journal of the International Association of Providers of AIDS Care (JIAPAC)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218823259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2325958218823259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325958218823259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:24Z","timestamp":1777502964000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2325958218823259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":19,"alternative-id":["10.1177\/2325958218823259"],"URL":"https:\/\/doi.org\/10.1177\/2325958218823259","relation":{},"ISSN":["2325-9582","2325-9582"],"issn-type":[{"value":"2325-9582","type":"print"},{"value":"2325-9582","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"2325958218823259"}}