{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:36Z","timestamp":1777853196945,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess prevalence of hyperlipidemia in patients receiving lopinavir boosted with ritonavir (LPV\/r) and atazanavir boosted with ritonavir (ATV\/r) antiretroviral drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>HIV-infected patients (300) were recruited in the study between December 2015 and April 2016. Lipid profile including triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Prevalence of derangement in TG was 71.0% in patients using LPV\/r compared to 44% in those using ATV\/r ( P = .01). Use of LPV\/r was independently associated with increased total cholesterol (TC; P = .001) and TG ( P = .0003). Females had raised levels of TC compared to males ( P = .00008). Body mass index of \u2265 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was also associated with raised TC ( P = .002) and LDL-C ( P = .006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LPV\/r was significantly associated with lipid derangements, indicating the need to regularly monitor lipid profile in patients using LPV\/r.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325958219841908","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T04:45:02Z","timestamp":1555562702000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Assessment of the Magnitude of Hyperlipidemia in HIV-Infected Patients Receiving Lopinavir\/r- and Atazanavir\/r-Based Antiretroviral Drugs"],"prefix":"10.1177","volume":"18","author":[{"given":"Esther","family":"Muya","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-9187","authenticated-orcid":false,"given":"Appolinary","family":"Kamuhabwa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"bibr1-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-904"},{"key":"bibr2-2325958219841908","first-page":"1","volume":"7","author":"Husain NEO","year":"2015","journal-title":"HIV\/AIDS (Auckland, NZ)"},{"key":"bibr3-2325958219841908","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070457"},{"key":"bibr4-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31821db92a"},{"key":"bibr5-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328355ab72"},{"key":"bibr6-2325958219841908","first-page":"E93","volume":"9","author":"Nigatu T","year":"2012","journal-title":"Prev Chronic Dis"},{"issue":"1","key":"bibr7-2325958219841908","first-page":"49","volume":"13","author":"Estrada V","year":"2011","journal-title":"AIDS Rev"},{"key":"bibr8-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X65439"},{"key":"bibr9-2325958219841908","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.4.918"},{"key":"bibr10-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-3-2"},{"key":"bibr11-2325958219841908","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-9-31"},{"key":"bibr12-2325958219841908","doi-asserted-by":"publisher","DOI":"10.4137\/IDRT.S10044"},{"key":"bibr13-2325958219841908","unstructured":"American Association of Clinical Endocrinologists\u2019 guidelines for management of dyslipidemia and prevention of atherosclerosis. 2000 March-April. 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