{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:46Z","timestamp":1777853206943,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23 AI104315"],"award-info":[{"award-number":["K23 AI104315"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a strong predictor of viral suppression in persons living with HIV (PLWH). Its association with antiretroviral therapy (ART) resistance remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Blood was collected in PLWH receiving TDF-containing ART enrolled in a 48-week study. Tenofovir diphosphate\/emtricitabine triphosphate (FTC-TP) were quantified from the same sample as HIV viral load (VL) in PLWH who developed resistance within \u226412 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study enrolled 807 participants, of whom 10 had new resistance-conferring mutations. Among these, median (interquartile range) TFV-DP and HIV VL were 956 (407-1510) fmol\/punch and 9840 (513-68,200) copies\/mL, respectively. Five had quantifiable FTC-TP in DBS. Based on previously published data, a TFV-DP concentration of 956 fmol\/punch would have an adjusted odds of virologic suppression of 32.8 versus TFV-DP &lt;350 fmol\/punch, making viremia of \u223c10,000 copies\/mL an unexpected outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Moderately high TFV-DP in DBS (700-1249 fmol\/punch) in PLWH with high viremia suggest that antiretroviral drug resistance might be present.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2325958219888457","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T09:13:03Z","timestamp":1574327583000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Moderately High Tenofovir Diphosphate in Dried Blood Spots Indicates Drug Resistance in Viremic Persons Living with HIV"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-1465","authenticated-orcid":false,"given":"Jenna Lynn","family":"Yager","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan Patrick","family":"Coyle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey Summer","family":"Coleman","sequence":"additional","affiliation":[{"name":"Duke University Hospital, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lane","family":"Bushman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Michael","family":"Gardner","sequence":"additional","affiliation":[{"name":"Denver Health Medical Center, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Colorado School of Public Health, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"MaWhinney","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Colorado School of Public Health, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Justice Kiser","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Ramon","family":"Castillo-Mancilla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"bibr1-2325958219888457","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-1-200007040-00004"},{"key":"bibr2-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328335cd8a"},{"key":"bibr3-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2014.0165"},{"key":"bibr4-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1310\/hct0805-282"},{"key":"bibr5-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832ba8ec"},{"key":"bibr6-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-018-0377-0"},{"key":"bibr7-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01710-17"},{"key":"bibr8-2325958219888457","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0089"},{"key":"bibr9-2325958219888457","volume-title":"Tenofovir diphosphate in dried 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