{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:46:43Z","timestamp":1792057603622,"version":"4.4.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Background: adherence and forgiveness are key factors for virologic success. We evaluated them for 3TC\/DTG. Methods: pharmacy refills were used to calculate the proportion of days covered (PDC). Forgiveness was calculated as the achieved rate of HIV-RNA threshold by a given level of imperfect adherence. Results: 240 PLWH were included. The median follow-up was 819 days (IQR 450-1459) for a total of 681 person\/years of follow-up. Adherence was very high with a median of 99% (IQR 95%-100%). Consequently, the virologic response was sustained with 83.8% of PLWH never exceeding a HIV RNA of 50 copies\/ml and 95.8% of subjects with a steadily HIV-RNA &lt; 200 copies\/ml. A PDC lower than 80% was associated with a negative outcome irrespective of the HIV-RNA threshold considered. Conclusions: The extensive virologic efficacy of 3TC\/DTG demonstrated both in clinical trials and real-world experiences seems to rely more on its friendliness than on its forgiveness.<\/jats:p>","DOI":"10.1177\/23259582221101815","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T02:29:27Z","timestamp":1655087367000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Adherence to and Forgiveness  of 3TC\/DTG in a Real-World Cohort"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-0072","authenticated-orcid":false,"given":"Franco","family":"Maggiolo","sequence":"first","affiliation":[{"name":"UOC Infectious Diseases, ASST Papa Giovanni XXII, Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Valenti","sequence":"additional","affiliation":[{"name":"UOC Infectious Diseases, ASST Papa 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