{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:12:34Z","timestamp":1783055554403,"version":"3.54.6"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008171","name":"Minneapolis Heart Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Chronic systemic inflammation from human immunodeficiency virus (HIV) may cause metabolic abnormalities in lipid metabolism. Additionally, the development of metabolic syndrome has been associated with specific anti-retroviral therapy, particularly dolutegravir. This study aimed to determine the prevalence and associated factors of metabolic syndrome among people living with HIV on dolutegravir-based anti-retroviral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an analytical cross-sectional study conducted between October 1, 2022, and March 31, 2023, among 312 people living with HIV. A structured questionnaire was used to collect socio-demographic and clinical characteristics including anthropometric indices and a blood pressure reading. A blood sample was collected to measure plasma glucose levels and serum lipid levels. The outcome being metabolic syndrome, odds ratios were evaluated using logistic regression analysis, and a P-value of &lt;.05 was considered statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of metabolic syndrome was 42.3%. Waist circumference (73%) and reduced high-density lipoprotein cholesterol (59.9%) were the most prevalent components. Factors associated with metabolic syndrome were patients aged 18\u201344 years (aOR: 3.10; 95% CI: 1.24\u20137.79; P = .016), female gender (aOR: 5.40; 95% CI: 2.07\u201314.13; P = .001), no physical activity (aOR: 4.00; 95% CI: 1.05\u201315.10; P = .042), and patients who earned &gt;300\u2005000 Tanzanian shillings per month (aOR: 2.15; 95% CI: 1.07\u20134.32; P = .032).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of metabolic syndrome among patients on dolutegravir-based therapy is high. There is a need to adhere to routine screening of metabolic syndrome among people living with HIV on dolutegravir-based anti-retroviral therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259582241306492","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T11:03:02Z","timestamp":1734951782000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic Syndrome and Associated Factors Among People Living With HIV on Dolutegravir-Based Antiretroviral  Therapy in Northern Tanzania"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9685-7765","authenticated-orcid":false,"given":"Tumaini E.","family":"Mirai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajiru G.","family":"Kilonzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-8042","authenticated-orcid":false,"given":"Abid M.","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Ali Ibrahim","family":"Muhina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman J.","family":"Kyala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette A.","family":"Marandu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Costantine","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elifuraha W.","family":"Mkwizu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Howlett","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania"},{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elichilia R.","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kilimanjaro Christian Medical 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