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Recognizing and addressing chemsex is crucial for human immunodeficiency virus (HIV) care providers, as it supports harm reduction and effective HIV prevention and treatment for GBMSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2017 to 2021, GBMSM at two sexual health clinics completed follow-up questionnaires. We identified chemsex trajectories using group-based modeling and assessed their association with depressive symptoms over two years using multivariable logistic models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 256 GBMSM, three chemsex patterns were found: \u201cnever or rarely engaged\u201d (87.4%), \u201cconsistently engaged\u201d (8.8%), and \u201chigh, decreasing and reinitiated\u201d (3.8%). There were no significant differences in depressive symptoms between the \u201cnever or rarely engaged\u201d group and the other patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study reveals diverse chemsex behaviors but does not provide clear evidence linking these patterns to differences in depressive symptoms among GBMSM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259582251339906","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T20:38:05Z","timestamp":1747341485000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A Longitudinal Investigation of Chemsex and Its Relationship with Depressive Symptoms Among Gay, Bisexual Men and Other Men Who Have Sex with Men in Taiwan"],"prefix":"10.1177","volume":"24","author":[{"given":"Shih-Chun","family":"Hua","sequence":"first","affiliation":[{"name":"College of Medicine, National Cheng Kung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane Wen-Wei","family":"Ku","sequence":"additional","affiliation":[{"name":"Taipei City Hospital Renai Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PoYao","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Health Behaviors and Community Sciences and Master of Public Health Program, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Ying","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Medicine, National Cheng Kung University"},{"name":"College of Medicine, National Cheng Kung 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