{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:50:36Z","timestamp":1785563436228,"version":"3.56.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    In people living with human immunodeficiency virus (PLHIV), hyperuricemia may result from antiretroviral therapy (ART)-induced metabolic changes, lifestyle behaviors, and individual host factors. However, there is a scarcity of data on the prevalence and determinants of hyperuricemia among PLHIV on ART in sub-Saharan Africa.\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aimed to assess the magnitude of hyperuricemia and its associated factors among PLHIV who enrolled in first-line ART in the Amhara Region, Ethiopia.\n                    <jats:bold>Method:<\/jats:bold>\n                    A multi-center, institution-based cross-sectional study was conducted from March 15 to June 15, 2024. Referral hospitals were selected through simple random sampling, and a total of 401 participants were enrolled from these hospitals using a systematic sampling approach. Data were collected using a structured questionnaire, patient chart review, physical measurements, and biochemical analysis. Hyperuricemia was defined as a serum uric acid level is &gt;6\u2005mg\/dL for females and &gt;7\u2005mg\/dL for males. Multivariable logistic regression was employed to identify the factors that are associated with hyperuricemia, and a statistical significance was decided at\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009\u2264\u2009.05.\n                    <jats:bold>Result:<\/jats:bold>\n                    The overall magnitude of hyperuricemia among PLHIV was 28.2% (95% confidence interval (CI): 23.7-32.5%). Male sex (AOR\u2009=\u20091.79, 95% CI: 1.07, 2.98), older age (AOR\u2009=\u20091.03; 95% CI: 1-1.06), obesity (AOR\u2009=\u20092.21; 95% CI: 1.04-4.73), and longer ART duration (AOR\u2009=\u20091.13; 95% CI: 1.01-1.27) were significantly associated with hyperuricemia.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our study found a relatively high prevalence of hyperuricemia (28.2%) among PLHIV on first-line ART. Significant associated factors included male sex, older age, obesity, and longer ART duration. Therefore, early screening, particularly in males, older adults, those with obesity, and long-term ART users, is essential to prevent complications.\n                  <\/jats:p>","DOI":"10.1177\/23259582251400988","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:56:30Z","timestamp":1764168990000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Magnitude of Hyperuricemia and Its Associated Factors Among People Living with Human Immunodeficiency Virus Who Enrolled in First-Line Antiretroviral Therapy in Amhara Region, Ethiopia"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6700-9972","authenticated-orcid":false,"given":"Mohammed","family":"Jemal","sequence":"first","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desalegn","family":"Abebaw","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabarak","family":"Malik","sequence":"additional","affiliation":[{"name":"Jimma University"},{"name":"Division of Research &amp; Development, Lovely Professional University, Phagwara, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muluken Getinet","family":"Mekuriaw","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmawi Abiy","family":"Abate","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8038-8505","authenticated-orcid":false,"given":"Temechew Munaw","family":"Abebe","sequence":"additional","affiliation":[{"name":"Injibara University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilahun","family":"Bitew","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enatnesh Essa","family":"Osman","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adane","family":"Adugna","sequence":"additional","affiliation":[{"name":"Debre Markos University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774913255"},{"issue":"7","key":"e_1_3_3_3_2","first-page":"3167","article-title":"Update on the epidemiology, genetics, and therapeutic options of hyperuricemia","volume":"12","author":"Li L","year":"2020","unstructured":"Li L, Zhang Y, Zeng C. 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