{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:08:34Z","timestamp":1777853314116,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum Alanine aminotransferase to High density lipoprotein cholesterol ratio (ALT-to-HDL-C ratio) has been identified as a significant predictor of non-alcoholic fatty liver disease, a hepatic manifestation of metabolic syndrome. This study investigated the association between serum aminotransferases to high-density lipoprotein cholesterol ratios and metabolic syndrome (MetS) among people living with HIV (PLWH) on Dolutegravir (DTG)-based antiretroviral therapy (ART) in South Western Uganda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis study from June 15, 2025 to August 20, 2025 using a dataset generated from hospital-based cross-sectional study that investigated an association between aspartate aminotransferase to alanine aminotransferase ratio and MetS among 377 PLWH who were on DTG-based ART at Ruhoko Health Centre IV, South Western Uganda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of MetS was 44.6%(168\/377); 95% CI: 39.6 - 49.6 and significantly increased from the lowest to the highest ALT-to-HDL-C ratio tertiles (30.2% vs 47.7% vs 56.1%, p\u2009&lt;\u20090.001). In the adjusted model, higher ALT-to-HDL-C ratio was significantly associated with MetS. Individuals in the second tertile had 2.35-fold higher odds (aOR 2.35, 95% CI: 1.26\u20134.41, p\u2009=\u20090.008), and those in the third tertile had over fourfold higher odds (aOR 4.65, 95% CI: 2.25\u20139.61, p\u2009&lt;\u20090.001) of MetS compared to the lowest tertile. ALT-to-HDL-C ratio at an optimal cutoff of 0.33 had a significant ability (AUC=0.820, 95%CI: 0.782 - 0.861) to differentiate between participants with MetS from those without MetS at a sensitivity of 92% and specificity of 54%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher ALT-to-HDL-C ratio is potentially associated with MetS. Since both ALT and HDL-C are routine measurements in HIV Care, this warrants further studies on the potential of ALT-to-HDL-C ratio as a biomarker for MetS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259582261420274","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:45:20Z","timestamp":1770140720000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between High Serum Alanine Aminotransferase to High Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome among People Living with HIV on Dolutegravir-Based ART in South-Western Uganda"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4235-1003","authenticated-orcid":false,"given":"Charles Nkubi","family":"Bagenda","sequence":"first","affiliation":[{"name":"Mbarara University of Science and Technology"},{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Kampala City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Nantongo","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Kampala City, Uganda"},{"name":"Department of Medical Laboratory, Joint Clinical Research Centre, Gulu City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3947-3864","authenticated-orcid":false,"given":"Michael Junior","family":"Mugisa","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"},{"name":"Department of Medical Laboratory Technology, Mayanja Memorial Medical Training Institute, Mbarara City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blendar","family":"Ainebyoona","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Kampala City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Oyuru","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Nzaramba","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jazira","family":"Tumusiime","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Lubwama","sequence":"additional","affiliation":[{"name":"Mountains of the Moon University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-4617","authenticated-orcid":false,"given":"Benson","family":"Musinguzi","sequence":"additional","affiliation":[{"name":"Muni University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence Obado","family":"Osuwat","sequence":"additional","affiliation":[{"name":"Soroti University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Ssenkumba","sequence":"additional","affiliation":[{"name":"Busitema University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald Ouma","family":"Omolo","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Metabolic syndrome and the risk of incident heart failure: a prospective cohort study","volume":"2025","author":"Wei H","unstructured":"Wei H, Qiu Z, Gao Z, Wei Y, Xiao J, Huang W. 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