{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:08:31Z","timestamp":1777853311299,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Assoc Provid AIDS Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dolutegravir (DTG)-based antiretroviral therapy (ART) has been associated with weight gain and obesity which are also linked to hepatocellular dysfunction. Despite these associations, the link between obesity indices and hepatocellular damage among people living with human immunodeficiency virus (PLWH) on DTG-based ART remains poorly understood. This study examined the association between obesity indices and elevated serum transaminases, markers of liver damage, among PLWH on DTG-based ART in Southwestern Uganda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study among 212 PLWH aged 18years and above who had been on DTG-based ART for \u22651 year at Municipal Health Centre IV, Southwestern Uganda. Data was collected using a semi-structured questionnaire. Anthropometric measurements were taken, and a blood sample collected from each participant for laboratory measurement of serum alanine and aspartate transaminase activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated serum transaminase activity was found in 12.7% (27\/212, 95% confidence interval (CI): 8.9%-18.0%) of participants. Participants with elevated transaminases had significantly higher median waist-to-hip ratio (0.88 vs 0.83, P\u2009&lt;\u20090.001) and waist circumference (WC) to body mass index (BMI) ratio (3.56 vs 3.42, P\u2009=\u20090.026) compared to those with normal activity. In multivariate analysis, only WC\/BMI ratio remained significantly associated (aOR = 3.68; 95% CI: 1.11-12.16; P\u2009=\u20090.033) with elevated serum transaminase activity. At an optimal cut-off of 3.45; sensitivity = 78%, specificity = 52%), WC\/BMI had significantly predictive power, (area under the curve= 0.651; 95% CI: 0.580-0.722) for elevated serum transaminase activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WC\/BMI ratio is a potential predictor of elevated transaminases among PLWH on DTG-based ART in South western Uganda.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259582261432050","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:28:07Z","timestamp":1773401287000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Waist Circumference to Body Mass Index Ratio and Elevated Serum Transaminases Among Patients on Dolutegravir-based Antiretroviral Therapy in South Western Uganda"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4235-1003","authenticated-orcid":false,"given":"Charles Nkubi","family":"Bagenda","sequence":"first","affiliation":[{"name":"Mbarara University of Science and Technology"},{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Kampala City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamella","family":"Kisakye","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hope","family":"Mudondo","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Nantongo","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Kampala City, Uganda"},{"name":"Joint Clinical Research Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milly Ketty","family":"Malinga","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Kigenyi","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Nanyijuka","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainea","family":"Ainebyona","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jazira","family":"Tumusiime","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3947-3864","authenticated-orcid":false,"given":"Michael Junior","family":"Mugisa","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology"},{"name":"Department of Medical Laboratory Technology, Mayanja Memorial Medical Training Institute, Mbarara City, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elastus","family":"Ssemwanga","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Mayanja Memorial Medical Training Institute, Mbarara City, Uganda"},{"name":"College of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Ampaire","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and 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Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00150-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-022-00442-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00141-8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac708"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2021.2003132"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002191"},{"issue":"1","key":"e_1_3_4_8_2","first-page":"4930355","article-title":"Dose-response associations of metabolic score for insulin resistance index with nonalcoholic fatty liver disease among a nonobese Chinese population: retrospective evidence from a population-based cohort study","volume":"2022","author":"Cai X","year":"2022","unstructured":"Cai X, Gao J, Hu J, et al. Dose-response associations of metabolic score for insulin resistance index with nonalcoholic fatty liver disease among a nonobese Chinese population: retrospective evidence from a population-based cohort study. Dis Markers. 2022;2022(1):4930355.","journal-title":"Dis Markers."},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_10_2","unstructured":"Rajesh Deshwal RD Sumit Arora SA. Serum alanine aminotransferase elevations in HIV positive patients on antiretroviral therapy in India. 2019."},{"issue":"1","key":"e_1_3_4_11_2","first-page":"1985452","article-title":"Liver enzymes abnormalities among highly active antiretroviral therapy experienced and HAART na\u00efve HIV-1 infected patients at Debre Tabor Hospital, North West Ethiopia: a comparative cross-sectional study","volume":"2016","author":"Shiferaw MB","year":"2016","unstructured":"Shiferaw MB, Tulu KT, Zegeye AM, Wubante AA. Liver enzymes abnormalities among highly active antiretroviral therapy experienced and HAART na\u00efve HIV-1 infected patients at Debre Tabor Hospital, North West Ethiopia: a comparative cross-sectional study. AIDS Res Treat. 2016;2016(1):1985452.","journal-title":"AIDS Res Treat."},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11342"},{"key":"e_1_3_4_13_2","unstructured":"Organization WH. WHO consultation on obesity. Obesity: preventing and managing the global epidemic. 2000:1\u2013253."},{"key":"e_1_3_4_14_2","unstructured":"Consultation W. Waist circumference and waist-hip ratio. Report of a WHO Expert Consultation. 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