{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:39:47Z","timestamp":1777880387429,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Journal of Sports Medicine"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Qualitative studies have explored changes in Tc-99m hydroxymethylene diphosphonate (HDP) uptake on single-photon emission computed tomography and computed tomography (SPECT\/CT) as a result of offloading after medial opening-wedge high tibial osteotomy (MOWHTO) in patients with medial compartment knee osteoarthritis. However, whether changes in the Tc-99m HDP uptake on SPECT\/CT reflect the degree of clinical improvement in postoperative outcomes, especially when using minimal clinically important differences (MCIDs), has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the association between changes in Tc-99m HDP uptake on SPECT\/CT and MCID-based improvement on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score in patients who underwent MOWHTO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Cross-sectional study; Level of evidence, 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included 35 knees in 31 patients who underwent MOWHTO. SPECT\/CT was performed preoperatively and 3 years postoperatively with clinical and radiological assessments. On SPECT\/CT, the knee joint was divided into 10 regions, and the radiotracer uptake amount of each region was divided by the uptake amount of the reference zone. Patients were divided into 2 groups based on whether they achieved the MCID of 16.1 points on the WOMAC at 3 years postoperatively, and changes in uptake amount on SPECT\/CT were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At 3 years postoperatively, 22 patients achieved the MCID on the WOMAC (62.9%; above-MCID group) and 13 patients did not (37.1%; below-MCID group). In the above-MCID group, significant improvement was observed in the WOMAC after MOWHTO (from 55.8 to 19.6; P &lt; .05); however, significant improvement was not observed in the below-MCID group (from 38.8 to 32.3; P = .100). Based on mean change of uptake on SPECT\/CT in each region, the above-MCID group showed significantly greater reduction of uptake on SPECT\/CT than the below-MCID group in the femoral anteromedial compartment ( P = .004), tibial anteromedial compartment ( P = .009), and tibial anterolateral compartment ( P = .031).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Reduction in radiotracer uptake on SPECT\/CT of the knee joint reflected clinical improvement in patient-reported outcomes following MOWHTO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259671221121083","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T12:58:00Z","timestamp":1665579480000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Usefulness of SPECT\/CT for Assessing Postoperative Outcomes After Medial Opening-Wedge High Tibial Osteotomy"],"prefix":"10.1177","volume":"10","author":[{"given":"Yong Gyu","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyukjin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, St Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon-si, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"In","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of 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