{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:45:11Z","timestamp":1777880711363,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Journal of Sports Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Allograft tendons are perceived to have a high ACL graft failure rate in primary anterior cruciate ligament (ACL) reconstruction (ACLR). Historical series may be biased by graft processing methods that degrade the biomechanical properties of donor tendons such as irradiation. Supercritical carbon dioxide (SCCO\n                      <jats:sub>2<\/jats:sub>\n                      ) is a validated method of terminally sterilizing biomaterials at physiological temperatures without irradiation, but in vivo use of SCCO\n                      <jats:sub>2<\/jats:sub>\n                      -processed tendon allografts for primary ACLR has not been reported to date.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>\n                      ACLR with SCCO\n                      <jats:sub>2<\/jats:sub>\n                      allografts would result in acceptable failure rates, subjective knee scores, and clinical evaluation at 2 years postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Case series; Level of evidence, 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients underwent primary ACLR with terminally sterilized SCCO\n                      <jats:sub>2<\/jats:sub>\n                      -processed human gracilis, peroneus longus, semitendinosus, tibialis anterior, and tibialis posterior tendon allografts. Patient demographics were collected, along with tendon donor age and sex. At 1 year postoperatively, subjective International Knee Documentation Committee (IKDC) and ACL\u2013Return to Sport After Injury (ACL-RSI) scores were collected, as well as clinical evaluation. At 2 years postoperatively, the IKDC and ACL-RSI scores were repeated, and return to sports and further knee injuries were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 144 patients with a medianage of 26 (IQR 14) years formed the study group. Patients were predominately male (58%). The loss to follow-up rate was 8% (n = 12). The mean age of allograft tendon donors was 37 (range 17-58) years, and the majority were male (83%). The mean allograft diameter was 8.9 \u00b1 1.0 mm. At 2 years, ACL graft failureoccurred in 5% (n = 7). All graft failureswere in patients aged \u226425 years ( P = .007). Neither donor age (\u226440 or &gt;40 years) nor donor sex was associated with graft failure ( P &gt; .05). The median IKDC subjective score was 95 and ACL-RSI score was 75. There were no revisions for sepsis within the first 2 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      SCCO\n                      <jats:sub>2<\/jats:sub>\n                      processing of allograft tendons demonstrated satisfactory clinical and patient-reported outcomes at 24 months postoperatively in a consecutive series of patients with primary ACLR, with similar ACL graft failure rates and subjective knee scores compared with those reported in published series of hamstring tendon autograft and fresh frozen nonirradiated allograft.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259671241254115","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T06:14:32Z","timestamp":1723184072000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of ACL Reconstruction Utilizing Supercritical CO\n                    <sub>2<\/sub>\n                    -Sterilized Allografts"],"prefix":"10.1177","volume":"12","author":[{"given":"John E.","family":"Farey","sequence":"first","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-8573","authenticated-orcid":false,"given":"Lucy J.","family":"Salmon","sequence":"additional","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"},{"name":"School of Medicine, University of Notre Dame Australia, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin P.","family":"Roe","sequence":"additional","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivianne","family":"Russell","sequence":"additional","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keran","family":"Sundaraj","sequence":"additional","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-5109","authenticated-orcid":false,"given":"Leo A.","family":"Pinczewski","sequence":"additional","affiliation":[{"name":"North Sydney Orthopaedic and Sports Medicine Centre, Mater Clinic, Wollstonecraft, New South Wales, Australia"},{"name":"School of Medicine, University of Notre Dame Australia, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"bibr1-23259671241254115","unstructured":"American Academy of Orthopaedic Surgeons. 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