{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:12:06Z","timestamp":1789456326841,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Journal of Sports Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aging is associated with degenerative changes in both bone and tendon tissues, leading to impaired healing at the bone-tendon interface (BTI) during rotator cuff repair. The role of fibulin-7 (FBLN7) in enhancing BTI healing in aged populations warrants an investigation because of its potential regenerative properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine whether FBLN7 can enhance tendon-bone healing and regeneration in a model of rotator cuff repair in aging mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 5 young (8 weeks old) and 5 aged (18 months old) C57BL\/6 mice were used for a baseline supraspinatus tendon\u2013humerus evaluation. Another 20 aged mice underwent rotator cuff repair and were allocated to either the FBLN7 (intervention) group (n = 10), receiving a fibrin sealant with FBLN7, or a control group (n = 10), receiving a standard fibrin sealant. Mice were euthanized at 4 (n = 5 per group) and 8 (n = 5 per group) weeks after surgery. The supraspinatus tendon\u2013humerus complexes were harvested for micro\u2013computed tomography, histological analysis, and biomechanical testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The expression of FBLN7 was significantly lower in aged mice at the BTI compared with young mice (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Histological and biomechanical assessments revealed that the FBLN7 group exhibited improved subchondral bone morphology (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) and denser cortical bone (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05), along with significantly higher failure loads and stiffness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05), compared with the control group. Additionally, the FBLN7 group demonstrated superior fibrocartilage formation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) and the upregulated expression of osteogenic (Runx2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01 at week 4 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 at week 8), chondrogenic (Sox9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01 at week 4 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 at week 8), and tenogenic (SCX;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 at week 4) factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FBLN7 significantly enhanced healing and regeneration at the BTI in aged mice, supporting its potential as a therapeutic intervention to improve rotator cuff repair outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>These findings highlight FBLN7\u2019s potential role in clinical sports medicine, suggesting that it could be utilized to promote better recovery and healing in aged patients undergoing rotator cuff repair, addressing a critical challenge in postoperative rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259671251410200","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:14:59Z","timestamp":1773756899000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fibulin-7 Promotes Short-term Histological Bone-Tendon Interface Healing in a Murine Rotator Cuff Repair Model"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2045-7823","authenticated-orcid":false,"given":"Junhao","family":"Li","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Jinan University, Guangzhou, China"},{"name":"Department of Orthopedics, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China"},{"name":"Department of Orthopedics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-7002","authenticated-orcid":false,"given":"Huabin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics, The Third 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