{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:06:34Z","timestamp":1789221994501,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Journal of Sports Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Platelet-rich plasma (PRP) has emerged as a nonoperative treatment option to manage pain and improve functionality in patients with partial-thickness rotator cuff tears. Previous studies examining the efficacy of PRP for the management of partial-thickness rotator cuff tears describe heterogeneous results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine whether platelet concentration of a PRP injection as management for partial-thickness rotator cuff tears affects visual analog scale (VAS) pain scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Systematic review; Level of evidence, 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to identify level 1 randomized controlled trials (RCTs) that evaluated the clinical efficacy of PRP for the management of partial-thickness rotator cuff tears. The search phrase used was \u201crotator cuff partial platelet rich plasma.\u201d Included RCTs were classified as utilizing high-dose or low-dose PRP based on their platelet concentration factor as greater than a 4-fold increase over whole blood. The primary outcome evaluated was the standardized mean differences of VAS scores. Mixed-effects and random effects meta-analyses were performed along with meta-regression to evaluate relationships in VAS scores associated with PRP platelet dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ten studies met inclusion and exclusion criteria, including a total of 635 patients (PRP, n = 307; control, n = 328). The mean patient age at the time of injection was 50.6 years, the mean follow-up time was 10.0 months, and the mean male sex distribution was 44.4%. Of the 10 studies, 6 studies utilized high-dose PRP and 4 studies utilized low-dose PRP. In both the meta-analysis and the meta-regression analyses, there were no significant differences in mean postinjection VAS scores between platelet dosage groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .36 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .37, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among level 1 RCTs reporting VAS pain scores after PRP injection for partial-thickness rotator cuff tears, platelet concentration was not significantly associated with improved pain outcomes. However, substantial heterogeneity and inconsistent reporting of PRP composition limit the certainty of this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23259671261480483","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:06:11Z","timestamp":1789038371000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet Concentration Is Not Associated With Improved Pain for Partial-Thickness Rotator Cuff Tears Treated With Platelet-Rich Plasma: A Systematic Review and Meta-analysis With Meta-regression of Level 1 Randomized Controlled Trials"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3790-5781","authenticated-orcid":false,"given":"Joseph J.","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Belk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Keeter","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilea A.","family":"Stepaniuk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie D.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-4373","authenticated-orcid":false,"given":"Jacob F.","family":"Oeding","sequence":"additional","affiliation":[{"name":"United States Olympic &amp; Paralympic Committee, Colorado Springs, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"McCarty","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"9","key":"e_1_3_3_2_2","first-page":"11918","article-title":"Efficacy of ultrasound guided platelet-rich plasma in the repair of partial and full-thickness supraspinatus tears","volume":"12","author":"Akan O","year":"2019","unstructured":"Akan O, Mete BD, Ko\u00e7yi\u011fit H, Bayram KB, Yilmaz HE, Tosun A. Efficacy of ultrasound guided platelet-rich plasma in the repair of partial and full-thickness supraspinatus tears. Int J Clin Exp Med. 2019;12(9):11918-11929.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2019.08.027"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519827947"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2024.03.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241283463"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001781"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515608485"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519881423"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2000.010001002.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000138251.07040.51"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000973"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509349921"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0b013e3182393fa1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jseint.2025.101409"},{"key":"e_1_3_3_16_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JP","year":"2011","unstructured":"Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. Cochrane; 2011."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2023.08.020"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.23732"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512437525"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513496542"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.10.037"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.06.028"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200110000-00002"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00793"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241303716"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515608481"},{"issue":"9","key":"e_1_3_3_27_2","article-title":"Platelet-rich plasma therapy for rotator cuff injuries: a comprehensive review of current evidence and future directions","volume":"16","author":"Rathod V","unstructured":"Rathod V, Shrivastav S. Platelet-rich plasma therapy for rotator cuff injuries: a comprehensive review of current evidence and future directions. Cureus. 16(9):e70042.","journal-title":"Cureus"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269215512448388"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.13107\/jocr.2025.v15.i03.5408"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519851097"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43166-021-00058-1"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211024937"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0483-0"}],"container-title":["Orthopaedic Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23259671261480483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23259671261480483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23259671261480483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:17:47Z","timestamp":1789219067000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23259671261480483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/23259671261480483"],"URL":"https:\/\/doi.org\/10.1177\/23259671261480483","relation":{},"ISSN":["2325-9671","2325-9671"],"issn-type":[{"value":"2325-9671","type":"print"},{"value":"2325-9671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"23259671261480483"}}